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Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity.
Bastid J, Regairaz A, Bonnefoy N, Déjou C, Giustiniani J, Laheurte C, Cochaud S, Laprevotte E, Funck-Brentano E, Hemon P, Gros L, Bec N, Larroque C, Alberici G, Bensussan A, Eliaou JF. Bastid J, et al. Among authors: bensussan a. Cancer Immunol Res. 2015 Mar;3(3):254-65. doi: 10.1158/2326-6066.CIR-14-0018. Epub 2014 Nov 17. Cancer Immunol Res. 2015. PMID: 25403716
Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity.
Le Bouteiller P, Barakonyi A, Giustiniani J, Lenfant F, Marie-Cardine A, Aguerre-Girr M, Rabot M, Hilgert I, Mami-Chouaib F, Tabiasco J, Boumsell L, Bensussan A. Le Bouteiller P, et al. Among authors: bensussan a. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16963-8. doi: 10.1073/pnas.012681099. Epub 2002 Dec 16. Proc Natl Acad Sci U S A. 2002. PMID: 12486241 Free PMC article.
Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells.
Fons P, Chabot S, Cartwright JE, Lenfant F, L'Faqihi F, Giustiniani J, Herault JP, Gueguen G, Bono F, Savi P, Aguerre-Girr M, Fournel S, Malecaze F, Bensussan A, Plouët J, Le Bouteiller P. Fons P, et al. Among authors: bensussan a. Blood. 2006 Oct 15;108(8):2608-15. doi: 10.1182/blood-2005-12-019919. Epub 2006 Jun 29. Blood. 2006. PMID: 16809620 Free article.
382 results