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How carvedilol does not activate β2-adrenoceptors.
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. Lefkowitz RJ, et al. Among authors: benovic jl. Nat Commun. 2023 Nov 30;14(1):7866. doi: 10.1038/s41467-023-42848-5. Nat Commun. 2023. PMID: 38036531 Free PMC article. No abstract available.
Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor.
Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Ippolito M, et al. Among authors: benovic jl. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120. doi: 10.1073/pnas.2302668120. Epub 2023 Jul 25. Proc Natl Acad Sci U S A. 2023. PMID: 37490535 Free PMC article.
β2 -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2 -adrenoceptor with possible implications for the treatment of asthma.
De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. De Pascali F, et al. Among authors: benovic jl. Br J Pharmacol. 2022 Oct;179(19):4692-4708. doi: 10.1111/bph.15900. Epub 2022 Jul 19. Br J Pharmacol. 2022. PMID: 35732075 Free PMC article.
Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner.
Okyere AD, Song J, Patwa V, Carter RL, Enjamuri N, Lucchese AM, Ibetti J, de Lucia C, Schumacher SM, Koch WJ, Cheung JY, Benovic JL, Tilley DG. Okyere AD, et al. Among authors: benovic jl. Cardiovasc Drugs Ther. 2023 Apr;37(2):245-256. doi: 10.1007/s10557-021-07299-4. Epub 2022 Jan 8. Cardiovasc Drugs Ther. 2023. PMID: 34997361 Free PMC article.
304 results