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Structure-activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity.
Bioorg Med Chem Lett. 2007 Feb 1;17(3):712-6. doi: 10.1016/j.bmcl.2006.10.082. Epub 2006 Nov 1.
Bioorg Med Chem Lett. 2007.
PMID: 17157017
3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Benjahad A, Guillemont J, Andries K, Nguyen CH, Grierson DS.
Benjahad A, et al.
Bioorg Med Chem Lett. 2003 Dec 15;13(24):4309-12. doi: 10.1016/j.bmcl.2003.09.045.
Bioorg Med Chem Lett. 2003.
PMID: 14643315
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4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
Benjahad A, Courté K, Guillemont J, Mabire D, Coupa S, Poncelet A, Csoka I, Andries K, Pauwels R, de Béthune MP, Monneret C, Bisagni E, Nguyen CH, Grierson DS.
Benjahad A, et al.
J Med Chem. 2004 Oct 21;47(22):5501-14. doi: 10.1021/jm0407658.
J Med Chem. 2004.
PMID: 15481987
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4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
Benjahad A, Croisy M, Monneret C, Bisagni E, Mabire D, Coupa S, Poncelet A, Csoka I, Guillemont J, Meyer C, Andries K, Pauwels R, de Béthune MP, Himmel DM, Das K, Arnold E, Nguyen CH, Grierson DS.
Benjahad A, et al.
J Med Chem. 2005 Mar 24;48(6):1948-64. doi: 10.1021/jm0408621.
J Med Chem. 2005.
PMID: 15771439
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Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
Guillemont J, Benjahad A, Oumouch S, Decrane L, Palandjian P, Vernier D, Queguiner L, Andries K, de Béthune MP, Hertogs K, Grierson DS, Nguyen CH.
Guillemont J, et al. Among authors: benjahad a.
J Med Chem. 2009 Dec 10;52(23):7473-87. doi: 10.1021/jm900802y.
J Med Chem. 2009.
PMID: 19645483
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Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E.
Himmel DM, et al. Among authors: benjahad a.
J Med Chem. 2005 Dec 1;48(24):7582-91. doi: 10.1021/jm0500323.
J Med Chem. 2005.
PMID: 16302798
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High specific radioactivity labeling of oligonucleotides with 3H-succinimidyl propionate.
Ledoan T, Auger R, Benjahad A, Tenu JP.
Ledoan T, et al. Among authors: benjahad a.
Nucleosides Nucleotides. 1999 Feb;18(2):277-89. doi: 10.1080/15257779908043074.
Nucleosides Nucleotides. 1999.
PMID: 10067277
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