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Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.
Benchekroun M, Ermolenko L, Tran MQ, Vagneux A, Nedev H, Delehouzé C, Souab M, Baratte B, Josselin B, Iorga BI, Ruchaud S, Bach S, Al-Mourabit A. Benchekroun M, et al. Eur J Med Chem. 2020 Sep 1;201:112337. doi: 10.1016/j.ejmech.2020.112337. Epub 2020 Jun 25. Eur J Med Chem. 2020. PMID: 32659605
Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D).
Romero E, Oueslati S, Benchekroun M, D'Hollander ACA, Ventre S, Vijayakumar K, Minard C, Exilie C, Tlili L, Retailleau P, Zavala A, Elisée E, Selwa E, Nguyen LA, Pruvost A, Naas T, Iorga BI, Dodd RH, Cariou K. Romero E, et al. Among authors: benchekroun m. Eur J Med Chem. 2021 Jul 5;219:113418. doi: 10.1016/j.ejmech.2021.113418. Epub 2021 Apr 2. Eur J Med Chem. 2021. PMID: 33862516
A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.
Naret T, Bignon J, Bernadat G, Benchekroun M, Levaique H, Lenoir C, Dubois J, Pruvost A, Saller F, Borgel D, Manoury B, Leblais V, Darrigrand R, Apcher S, Brion JD, Schmitt E, Leroux FR, Alami M, Hamze A. Naret T, et al. Among authors: benchekroun m. Eur J Med Chem. 2018 Jan 1;143:473-490. doi: 10.1016/j.ejmech.2017.11.055. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29202409
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
Benchekroun M, Romero A, Egea J, León R, Michalska P, Buendía I, Jimeno ML, Jun D, Janockova J, Sepsova V, Soukup O, Bautista-Aguilera OM, Refouvelet B, Ouari O, Marco-Contelles J, Ismaili L. Benchekroun M, et al. J Med Chem. 2016 Nov 10;59(21):9967-9973. doi: 10.1021/acs.jmedchem.6b01178. Epub 2016 Oct 31. J Med Chem. 2016. PMID: 27736061
Donepezil-ferulic acid hybrids as anti-Alzheimer drugs.
Benchekroun M, Ismaili L, Pudlo M, Luzet V, Gharbi T, Refouvelet B, Marco-Contelles J. Benchekroun M, et al. Future Med Chem. 2015;7(1):15-21. doi: 10.4155/fmc.14.148. Future Med Chem. 2015. PMID: 25582330
51 results