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Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Shapiro JS, et al. Among authors: ben sahra i. Nat Cell Biol. 2023 Oct;25(10):1478-1494. doi: 10.1038/s41556-023-01225-6. Epub 2023 Sep 25. Nat Cell Biol. 2023. PMID: 37749225
mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.
Sato T, Chang HC, Bayeva M, Shapiro JS, Ramos-Alonso L, Kouzu H, Jiang X, Liu T, Yar S, Sawicki KT, Chen C, Martínez-Pastor MT, Stumpo DJ, Schumacker PT, Blackshear PJ, Ben-Sahra I, Puig S, Ardehali H. Sato T, et al. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6291-E6300. doi: 10.1073/pnas.1804701115. Epub 2018 Jun 18. Proc Natl Acad Sci U S A. 2018. PMID: 29915044 Free PMC article.
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H. De Jesus A, et al. Mol Cell. 2022 Apr 7;82(7):1261-1277.e9. doi: 10.1016/j.molcel.2022.02.028. Epub 2022 Mar 18. Mol Cell. 2022. PMID: 35305311 Free PMC article.
GATOR2 rings GATOR1 to speak to mTORC1.
Sahu U, Ben-Sahra I. Sahu U, et al. Mol Cell. 2023 Jan 5;83(1):6-8. doi: 10.1016/j.molcel.2022.12.011. Mol Cell. 2023. PMID: 36608671 Free PMC article.
A spoonful of DHAP keeps mTORC1 running on sugars.
Hoxhaj G, Locasale JW, Ben-Sahra I. Hoxhaj G, et al. Nat Metab. 2020 Sep;2(9):801-802. doi: 10.1038/s42255-020-0246-1. Nat Metab. 2020. PMID: 32719540 No abstract available.
67 results