Ben-Sahra I - Search Results

1

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production.

Perrault EN, Shireman JM, Ali ES, Lin P, Preddy I, Park C, Budhiraja S, Baisiwala S, Dixit K, James CD, Heiland DH, Ben-Sahra I, Pott S, Basu A, Miska J, Ahmed AU. Perrault EN, et al. Among authors: ben sahra i. Sci Adv. 2023 May 19;9(20):eade7236. doi: 10.1126/sciadv.ade7236. Epub 2023 May 17. Sci Adv. 2023. PMID: 37196077 Free PMC article.

2

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

Robert G, Ben Sahra I, Puissant A, Colosetti P, Belhacene N, Gounon P, Hofman P, Bost F, Cassuto JP, Auberger P. Robert G, et al. PLoS One. 2009 Nov 18;4(11):e7889. doi: 10.1371/journal.pone.0007889. PLoS One. 2009. PMID: 19924252 Free PMC article.

3

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Lall R, et al. Cell Death Differ. 2014 May;21(5):836-44. doi: 10.1038/cdd.2014.24. Epub 2014 Feb 28. Cell Death Differ. 2014. PMID: 24583639 Free PMC article.

4

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.

Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T. Covarrubias AJ, et al. Elife. 2016 Feb 19;5:e11612. doi: 10.7554/eLife.11612. Elife. 2016. PMID: 26894960 Free PMC article.

5

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD. Ben-Sahra I, et al. Science. 2016 Feb 12;351(6274):728-733. doi: 10.1126/science.aad0489. Science. 2016. PMID: 26912861 Free PMC article.

6

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells.

Ben Sahra I, Tanti JF, Bost F. Ben Sahra I, et al. Autophagy. 2010 Jul;6(5):670-1. doi: 10.1158/0008-5472.CAN-09-2782. Autophagy. 2010. PMID: 20559023

7

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H₂S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Longchamp A, et al. Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001. Cell. 2018. PMID: 29570992 Free PMC article.

8

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Villa E, Ali ES, Sahu U, Ben-Sahra I. Villa E, et al. Cancers (Basel). 2019 May 17;11(5):688. doi: 10.3390/cancers11050688. Cancers (Basel). 2019. PMID: 31108873 Free PMC article. Review.

9

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I. Ali ES, et al. Mol Cell. 2020 Jun 18;78(6):1178-1191.e6. doi: 10.1016/j.molcel.2020.05.001. Epub 2020 Jun 1. Mol Cell. 2020. PMID: 32485148 Free PMC article.

10

mTORC1 stimulates cell growth through SAM synthesis and m⁶A mRNA-dependent control of protein synthesis.

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. Villa E, et al. Mol Cell. 2021 May 20;81(10):2076-2093.e9. doi: 10.1016/j.molcel.2021.03.009. Epub 2021 Mar 22. Mol Cell. 2021. PMID: 33756106 Free PMC article.

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