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Page 1
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.
Ma Q, Yang Q, Xu J, Sellers HG, Brown ZL, Liu Z, Bordan Z, Shi X, Zhao D, Cai Y, Pareek V, Zhang C, Wu G, Dong Z, Verin AD, Gan L, Du Q, Benkovic SJ, Xu S, Asara JM, Ben-Sahra I, Barman S, Su Y, Fulton DJR, Huo Y. Ma Q, et al. Eur Heart J. 2023 Apr 7;44(14):1265-1279. doi: 10.1093/eurheartj/ehad044. Eur Heart J. 2023. PMID: 36721994 Free PMC article.
mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.
Sato T, Chang HC, Bayeva M, Shapiro JS, Ramos-Alonso L, Kouzu H, Jiang X, Liu T, Yar S, Sawicki KT, Chen C, Martínez-Pastor MT, Stumpo DJ, Schumacker PT, Blackshear PJ, Ben-Sahra I, Puig S, Ardehali H. Sato T, et al. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6291-E6300. doi: 10.1073/pnas.1804701115. Epub 2018 Jun 18. Proc Natl Acad Sci U S A. 2018. PMID: 29915044 Free PMC article.
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H. De Jesus A, et al. Mol Cell. 2022 Apr 7;82(7):1261-1277.e9. doi: 10.1016/j.molcel.2022.02.028. Epub 2022 Mar 18. Mol Cell. 2022. PMID: 35305311 Free PMC article.
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.
Kaminski L, Torrino S, Dufies M, Djabari Z, Haider R, Roustan FR, Jaune E, Laurent K, Nottet N, Michiels JF, Gesson M, Rocchi S, Mazure NM, Durand M, Tanti JF, Ambrosetti D, Clavel S, Ben-Sahra I, Bost F. Kaminski L, et al. Cancer Res. 2019 Jul 1;79(13):3268-3280. doi: 10.1158/0008-5472.CAN-18-2043. Epub 2019 May 7. Cancer Res. 2019. PMID: 31064849 Free PMC article.
GATOR2 rings GATOR1 to speak to mTORC1.
Sahu U, Ben-Sahra I. Sahu U, et al. Mol Cell. 2023 Jan 5;83(1):6-8. doi: 10.1016/j.molcel.2022.12.011. Mol Cell. 2023. PMID: 36608671 Free PMC article.
The cell cycle loops UTP around CAD.
Sahu U, Ben-Sahra I. Sahu U, et al. Nat Metab. 2023 Feb;5(2):199-200. doi: 10.1038/s42255-023-00737-7. Nat Metab. 2023. PMID: 36747087 No abstract available.
67 results