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Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3.
Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, Swisa A, Kolodkin-Gal D, Ximénez-Embún P, Lowe R, Martín-Martín B, Peinado H, Muñoz J, Fleck RA, Dor Y, Ben-Porath I, Vossenkamper A, Muñoz-Espin D, O'Loghlen A. Borghesan M, et al. Among authors: ben porath i. Cell Rep. 2019 Jun 25;27(13):3956-3971.e6. doi: 10.1016/j.celrep.2019.05.095. Cell Rep. 2019. PMID: 31242426 Free PMC article.
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I. Helman A, et al. Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7. Nat Med. 2016. PMID: 26950362 Free PMC article.
Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions.
Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, Kalifa R, Horwitz S, Khalatnik Y, Hochner-Ger A, Imam A, Demma JA, Winter E, Benyamini H, Elgavish S, Khatib AA, Meir K, Atlan K, Pikarsky E, Parnas O, Dor Y, Zamir G, Ben-Porath I, Krizhanovsky V. Kolodkin-Gal D, et al. Among authors: ben porath i. Gut. 2022 Feb;71(2):345-355. doi: 10.1136/gutjnl-2020-321112. Epub 2021 Mar 1. Gut. 2022. PMID: 33649045 Free PMC article.
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness.
Patra M, Klochendler A, Condiotti R, Kaffe B, Elgavish S, Drawshy Z, Avrahami D, Narita M, Hofree M, Drier Y, Meshorer E, Dor Y, Ben-Porath I. Patra M, et al. Among authors: ben porath i. Nucleic Acids Res. 2024 Apr 29:gkae313. doi: 10.1093/nar/gkae313. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38682582
Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer.
Granit RZ, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, Dalin S, Winter E, Nevo Y, Carmon E, Sella T, Sonnenblick A, Peretz T, Lehmann U, Paz K, Piccioni F, Regev A, Root DE, Ben-Porath I. Granit RZ, et al. Among authors: ben porath i. Cell Rep. 2018 Sep 18;24(12):3237-3250. doi: 10.1016/j.celrep.2018.08.053. Cell Rep. 2018. PMID: 30232005 Free article.
Senescent stromal cells: roles in the tumor microenvironment.
Gabai Y, Assouline B, Ben-Porath I. Gabai Y, et al. Among authors: ben porath i. Trends Cancer. 2023 Jan;9(1):28-41. doi: 10.1016/j.trecan.2022.09.002. Epub 2022 Oct 5. Trends Cancer. 2023. PMID: 36208990 Review.
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