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Enhanced T cell effector activity by targeting the Mediator kinase module.
Freitas KA, Belk JA, Sotillo E, Quinn PJ, Ramello MC, Malipatlolla M, Daniel B, Sandor K, Klysz D, Bjelajac J, Xu P, Burdsall KA, Tieu V, Duong VT, Donovan MG, Weber EW, Chang HY, Majzner RG, Espinosa JM, Satpathy AT, Mackall CL. Freitas KA, et al. Among authors: belk ja. Science. 2022 Nov 11;378(6620):eabn5647. doi: 10.1126/science.abn5647. Epub 2022 Nov 11. Science. 2022. PMID: 36356142 Free PMC article.
Loquacious modulates flaviviral RNA replication in mosquito cells.
Shivaprasad S, Weng KF, Ooi YS, Belk J, Carette JE, Flynn R, Sarnow P. Shivaprasad S, et al. PLoS Pathog. 2022 Apr 28;18(4):e1010163. doi: 10.1371/journal.ppat.1010163. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35482886 Free PMC article.
Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection.
Flynn RA, Belk JA, Qi Y, Yasumoto Y, Schmitz CO, Mumbach MR, Limaye A, Wei J, Alfajaro MM, Parker KR, Chang HY, Horvath TL, Carette JE, Bertozzi C, Wilen CB, Satpathy AT. Flynn RA, et al. Among authors: belk ja. bioRxiv [Preprint]. 2020 Oct 6:2020.10.06.327445. doi: 10.1101/2020.10.06.327445. bioRxiv. 2020. PMID: 33052334 Free PMC article. Updated. Preprint.
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.
Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, Wilen CB, Satpathy AT. Flynn RA, et al. Among authors: belk ja. Cell. 2021 Apr 29;184(9):2394-2411.e16. doi: 10.1016/j.cell.2021.03.012. Epub 2021 Mar 11. Cell. 2021. PMID: 33743211 Free PMC article.
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Weber EW, Parker KR, Sotillo E, Lynn RC, Anbunathan H, Lattin J, Good Z, Belk JA, Daniel B, Klysz D, Malipatlolla M, Xu P, Bashti M, Heitzeneder S, Labanieh L, Vandris P, Majzner RG, Qi Y, Sandor K, Chen LC, Prabhu S, Gentles AJ, Wandless TJ, Satpathy AT, Chang HY, Mackall CL. Weber EW, et al. Among authors: belk ja. Science. 2021 Apr 2;372(6537):eaba1786. doi: 10.1126/science.aba1786. Science. 2021. PMID: 33795428 Free PMC article.
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS. Warshauer JT, et al. Among authors: belk ja. J Exp Med. 2021 Aug 2;218(8):e20210759. doi: 10.1084/jem.20210759. Epub 2021 Jun 11. J Exp Med. 2021. PMID: 34115115 Free PMC article.
ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY. Hung KL, et al. Among authors: belk ja. Nature. 2021 Dec;600(7890):731-736. doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819668 Free PMC article.
Epigenetic regulation of T cell exhaustion.
Belk JA, Daniel B, Satpathy AT. Belk JA, et al. Nat Immunol. 2022 Jun;23(6):848-860. doi: 10.1038/s41590-022-01224-z. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624210 Free PMC article. Review.
30 results