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Page 1
Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Belema M, Nguyen VN, Bachand C, Deon DH, Goodrich JT, James CA, Lavoie R, Lopez OD, Martel A, Romine JL, Ruediger EH, Snyder LB, St Laurent DR, Yang F, Zhu J, Wong HS, Langley DR, Adams SP, Cantor GH, Chimalakonda A, Fura A, Johnson BM, Knipe JO, Parker DD, Santone KS, Fridell RA, Lemm JA, O'Boyle DR 2nd, Colonno RJ, Gao M, Meanwell NA, Hamann LG. Belema M, et al. J Med Chem. 2014 Mar 13;57(5):2013-32. doi: 10.1021/jm401836p. Epub 2014 Feb 12. J Med Chem. 2014. PMID: 24521299
Developments in antiviral drug design, discovery and development in 2004.
Meanwell NA, Belema M, Carini DJ, D'Andrea SV, Kadow JF, Krystal M, Naidu BN, Regueiro-Ren A, Scola PM, Sit SY, Walker MA, Wang T, Yeung KS. Meanwell NA, et al. Among authors: belema m. Curr Drug Targets Infect Disord. 2005 Dec;5(4):307-400. doi: 10.2174/156800505774912893. Curr Drug Targets Infect Disord. 2005. PMID: 16535860 Review.
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.
Beaulieu F, Ouellet C, Ruediger EH, Belema M, Qiu Y, Yang X, Banville J, Burke JR, Gregor KR, MacMaster JF, Martel A, McIntyre KW, Pattoli MA, Zusi FC, Vyas D. Beaulieu F, et al. Among authors: belema m. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1233-7. doi: 10.1016/j.bmcl.2006.12.017. Epub 2006 Dec 9. Bioorg Med Chem Lett. 2007. PMID: 17197177
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, Grasela DM, Meanwell NA, Hamann LG. Gao M, et al. Among authors: belema m. Nature. 2010 May 6;465(7294):96-100. doi: 10.1038/nature08960. Epub 2010 Apr 21. Nature. 2010. PMID: 20410884 Free PMC article. Clinical Trial.
HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.
St Laurent DR, Belema M, Gao M, Goodrich J, Kakarla R, Knipe JO, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle D 2nd, Qiu Y, Romine JL, Serrano-Wu MH, Sun JH, Valera L, Yang F, Yang X, Meanwell NA, Snyder LB. St Laurent DR, et al. Among authors: belema m. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6063-6. doi: 10.1016/j.bmcl.2012.08.049. Epub 2012 Aug 21. Bioorg Med Chem Lett. 2012. PMID: 22959243
HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.
Lopez OD, Nguyen VN, St Laurent DR, Belema M, Serrano-Wu MH, Goodrich JT, Yang F, Qiu Y, Ripka AS, Nower PT, Valera L, Liu M, O'Boyle DR 2nd, Sun JH, Fridell RA, Lemm JA, Gao M, Good AC, Meanwell NA, Snyder LB. Lopez OD, et al. Among authors: belema m. Bioorg Med Chem Lett. 2013 Feb 1;23(3):779-84. doi: 10.1016/j.bmcl.2012.11.086. Epub 2012 Dec 3. Bioorg Med Chem Lett. 2013. PMID: 23273521
HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.
St Laurent DR, Serrano-Wu MH, Belema M, Ding M, Fang H, Gao M, Goodrich JT, Krause RG, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle DR 2nd, Pearce BC, Romine JL, Valera L, Sun JH, Wang YK, Yang F, Yang X, Meanwell NA, Snyder LB. St Laurent DR, et al. Among authors: belema m. J Med Chem. 2014 Mar 13;57(5):1976-94. doi: 10.1021/jm301796k. Epub 2013 Apr 10. J Med Chem. 2014. PMID: 23573957
22 results