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First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα.
Poirier N, Baccelli I, Belarif L, Abès R, Teppaz G, Mary C, Poli S, Fromond C, Girault I, Pengam S, Soma E, De Sa F, Conduzorgues JP, Braudeau C, Josien R, Volckaert B, Costantini D, Corallo F. Poirier N, et al. Among authors: belarif l. J Immunol. 2023 Mar 15;210(6):753-763. doi: 10.4049/jimmunol.2200635. J Immunol. 2023. PMID: 36734626 Clinical Trial.
Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution.
Trilleaud C, Gauttier V, Biteau K, Girault I, Belarif L, Mary C, Pengam S, Teppaz G, Thepenier V, Danger R, Robert-Siegwald G, Néel M, Bruneau S, Glémain A, Néel A, Poupon A, Mosnier JF, Chêne G, Dubourdeau M, Blancho G, Vanhove B, Poirier N. Trilleaud C, et al. Among authors: belarif l. Sci Adv. 2021 Apr 2;7(14):eabd1453. doi: 10.1126/sciadv.abd1453. Print 2021 Apr. Sci Adv. 2021. PMID: 33811066 Free PMC article.
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E, Gauttier V, Kucik A, Thepenier V, Martin JC, Chang C, Rahman A, Guen NS, Braudeau C, Abidi A, David G, Malard F, Takoudju C, Martinet B, Gérard N, Neveu I, Neunlist M, Coron E, MacDonald TT, Desreumaux P, Mai HL, Le Bas-Bernardet S, Mosnier JF, Merad M, Josien R, Brouard S, Soulillou JP, Blancho G, Bourreille A, Naveilhan P, Vanhove B, Poirier N. Belarif L, et al. J Clin Invest. 2019 Apr 2;129(5):1910-1925. doi: 10.1172/JCI121668. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939120 Free PMC article.
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.
Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E, Pengam S, Largy E, Delobel A, Martinet B, Le Bas-Bernardet S, Brouard S, Soulillou JP, Degauque N, Blancho G, Vanhove B, Poirier N. Belarif L, et al. Nat Commun. 2018 Oct 26;9(1):4483. doi: 10.1038/s41467-018-06804-y. Nat Commun. 2018. PMID: 30367166 Free PMC article.
11 results