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A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.
Rivaud MR, Jansen JA, Postema PG, Nannenberg EA, Mizusawa Y, van der Nagel R, Wolswinkel R, van der Made I, Marchal GA, Rajamani S, Belardinelli L, van Tintelen JP, Tanck MWT, van der Wal AC, de Bakker JMT, van Rijen HV, Creemers EE, Wilde AAM, van den Berg MP, van Veen TAB, Bezzina CR, Remme CA. Rivaud MR, et al. Among authors: belardinelli l. Eur Heart J. 2018 Aug 14;39(31):2898-2907. doi: 10.1093/eurheartj/ehy247. Eur Heart J. 2018. PMID: 29718149
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Rivaud MR, Marchal GA, Wolswinkel R, Jansen JA, van der Made I, Beekman L, Ruiz-Villalba A, Baartscheer A, Rajamani S, Belardinelli L, van Veen TAB, Basso C, Thiene G, Creemers EE, Bezzina CR, Remme CA. Rivaud MR, et al. Among authors: belardinelli l. Europace. 2020 Oct 1;22(10):1579-1589. doi: 10.1093/europace/euaa127. Europace. 2020. PMID: 32778883 Free PMC article.
Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation.
Justo F, Fuller H, Nearing BD, Rajamani S, Belardinelli L, Verrier RL. Justo F, et al. Among authors: belardinelli l. Heart Rhythm. 2016 Sep;13(9):1860-7. doi: 10.1016/j.hrthm.2016.06.020. Epub 2016 Jun 16. Heart Rhythm. 2016. PMID: 27317981
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA. Bossu A, et al. Among authors: belardinelli l. Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6. Br J Pharmacol. 2018. PMID: 29582428 Free PMC article.
386 results