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Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A. Marx U, et al. Among authors: beken s. ALTEX. 2016;33(3):272-321. doi: 10.14573/altex.1603161. Epub 2016 May 15. ALTEX. 2016. PMID: 27180100 Free PMC article. Review.
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development.
Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A. Marx U, et al. Among authors: beken s. ALTEX. 2020;37(3):365-394. doi: 10.14573/altex.2001241. Epub 2020 Feb 28. ALTEX. 2020. PMID: 32113184 Free PMC article.
Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.
Ramirez T, Beken S, Chlebus M, Ellis G, Griesinger C, De Jonghe S, Manou I, Mehling A, Reisinger K, Rossi LH, van Benthem J, van der Laan JW, Weissenhorn R, Sauer UG. Ramirez T, et al. Among authors: beken s. Regul Toxicol Pharmacol. 2015 Oct;73(1):210-26. doi: 10.1016/j.yrtph.2015.07.007. Epub 2015 Jul 15. Regul Toxicol Pharmacol. 2015. PMID: 26188116
Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects.
Theunissen PT, Beken S, Beyer BK, Breslin WJ, Cappon GD, Chen CL, Chmielewski G, De Schaepdrijver L, Enright B, Foreman JE, Harrouk W, Hew KW, Hoberman AM, Hui JY, Knudsen TB, Laffan SB, Makris SL, Martin M, McNerney ME, Siezen CL, Stanislaus DJ, Stewart J, Thompson KE, Tornesi B, Van der Laan JW, Weinbauer GF, Wood S, Piersma AH. Theunissen PT, et al. Among authors: beken s. Crit Rev Toxicol. 2016 Nov;46(10):900-910. doi: 10.1080/10408444.2016.1224807. Epub 2016 Oct 19. Crit Rev Toxicol. 2016. PMID: 27848393 Free PMC article. Review.
Organ-on-a-chip: current gaps and future directions.
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W, Amour A. Candarlioglu PL, et al. Among authors: beken s. Biochem Soc Trans. 2022 Apr 29;50(2):665-673. doi: 10.1042/BST20200661. Biochem Soc Trans. 2022. PMID: 35437569 Free PMC article.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Prior H, Baldrick P, Beken S, Booler H, Bower N, Brooker P, Brown P, Burlinson B, Burns-Naas LA, Casey W, Chapman M, Clarke D, de Haan L, Doehr O, Downes N, Flaherty M, Gellatly N, Moesgaard SG, Harris J, Holbrook M, Hui J, Jones D, Jones K, Kedar H, Mahl A, Manninen A, McGuire A, Mortimer-Cassen E, Peraza M, Pugsley MK, Richard J, Roberts R, Roosen W, Rothfuss A, Schoenmakers A, Sewell F, Weaver R, Weir L, Wolfreys A, Kimber I. Prior H, et al. Among authors: beken s. Regul Toxicol Pharmacol. 2020 Jun;113:104624. doi: 10.1016/j.yrtph.2020.104624. Epub 2020 Feb 29. Regul Toxicol Pharmacol. 2020. PMID: 32126256 Free article.
Building confidence in skin sensitisation potency assessment using new approach methodologies: report of the 3rd EPAA Partners Forum, Brussels, 28th October 2019.
Basketter D, Beken S, Bender H, Bridges J, Casati S, Corvaro M, Cuvellier S, Hubesch B, Irizar A, Jacobs MN, Kern P, Lamplmair F, Manou I, Müller BP, Roggeband R, Rossi LH. Basketter D, et al. Among authors: beken s. Regul Toxicol Pharmacol. 2020 Nov;117:104767. doi: 10.1016/j.yrtph.2020.104767. Epub 2020 Aug 28. Regul Toxicol Pharmacol. 2020. PMID: 32866543 Free article. Review.
115 results