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Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing.
Chen CX, You Z, Abdian N, Sirois J, Shlaifer I, Tabatabaei M, Boivin MN, Gaborieau L, Karamchandani J, Beitel LK, Fon EA, Durcan TM. Chen CX, et al. Among authors: beitel lk. Stem Cell Res. 2022 Jul;62:102806. doi: 10.1016/j.scr.2022.102806. Epub 2022 May 4. Stem Cell Res. 2022. PMID: 35561458 Free article.
Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy.
Mohamed NV, Sirois J, Ramamurthy J, Mathur M, Lépine P, Deneault E, Maussion G, Nicouleau M, Chen CX, Abdian N, Soubannier V, Cai E, Nami H, Thomas RA, Wen D, Tabatabaei M, Beitel LK, Singh Dolt K, Karamchandani J, Stratton JA, Kunath T, Fon EA, Durcan TM. Mohamed NV, et al. Among authors: beitel lk. Brain Commun. 2021 Sep 25;3(4):fcab223. doi: 10.1093/braincomms/fcab223. eCollection 2021. Brain Commun. 2021. PMID: 34632384 Free PMC article.
Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson's associated GBA gene.
X-Q Chen C, Deneault E, Abdian N, You Z, Sirois J, Nicouleau M, Shlaifer I, Villegas L, Boivin MN, Gaborieau L, Karamchandani J, Beitel LK, Fon EA, Durcan TM. X-Q Chen C, et al. Among authors: beitel lk. Stem Cell Res. 2022 Oct;64:102919. doi: 10.1016/j.scr.2022.102919. Epub 2022 Sep 15. Stem Cell Res. 2022. PMID: 36130446 Free article.
68 results