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Page 1
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. Behrens G, et al. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. Nat Immunol. 2021. PMID: 34811541 Free PMC article.
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V. Essig K, et al. Among authors: behrens g. Immunity. 2017 Dec 19;47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12. Immunity. 2017. PMID: 29246441 Free article.
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V. Rehage N, et al. Among authors: behrens g. Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1. Nat Commun. 2018. PMID: 29352114 Free PMC article.
Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Essig K, Kronbeck N, Guimaraes JC, Lohs C, Schlundt A, Hoffmann A, Behrens G, Brenner S, Kowalska J, Lopez-Rodriguez C, Jemielity J, Holtmann H, Reiche K, Hackermüller J, Sattler M, Zavolan M, Heissmeyer V. Essig K, et al. Among authors: behrens g. Nat Commun. 2018 Sep 19;9(1):3810. doi: 10.1038/s41467-018-06184-3. Nat Commun. 2018. PMID: 30232334 Free PMC article.
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E. von Gamm M, et al. Among authors: behrens g. J Exp Med. 2019 Jul 1;216(7):1700-1723. doi: 10.1084/jem.20181762. Epub 2019 May 24. J Exp Med. 2019. PMID: 31126966 Free PMC article.
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F. Tavernier SJ, et al. Among authors: behrens g. Nat Commun. 2019 Oct 21;10(1):4779. doi: 10.1038/s41467-019-12704-6. Nat Commun. 2019. PMID: 31636267 Free PMC article.
Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F. Tavernier SJ, et al. Among authors: behrens g. Nat Commun. 2019 Nov 20;10(1):5337. doi: 10.1038/s41467-019-13379-9. Nat Commun. 2019. PMID: 31745085 Free PMC article.
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
Hoefig KP, Reim A, Gallus C, Wong EH, Behrens G, Conrad C, Xu M, Kifinger L, Ito-Kureha T, Defourny KAY, Geerlof A, Mautner J, Hauck SM, Baumjohann D, Feederle R, Mann M, Wierer M, Glasmacher E, Heissmeyer V. Hoefig KP, et al. Among authors: behrens g. Nat Commun. 2021 Sep 1;12(1):5208. doi: 10.1038/s41467-021-25345-5. Nat Commun. 2021. PMID: 34471108 Free PMC article.
328 results