Begtrup M - Search Results

1

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism.

Thomsen AE, Friedrichsen GM, Sørensen AH, Andersen R, Nielsen CU, Brodin B, Begtrup M, Frokjaer S, Steffansen B. Thomsen AE, et al. Among authors: begtrup m. J Control Release. 2003 Jan 17;86(2-3):279-92. doi: 10.1016/s0168-3659(02)00413-3. J Control Release. 2003. PMID: 12526824

2

Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1.

Thorn K, Andersen R, Christensen J, Jakobsen P, Nielsen CU, Steffansen B, Begtrup M. Thorn K, et al. Among authors: begtrup m. ChemMedChem. 2007 Apr;2(4):479-87. doi: 10.1002/cmdc.200600200. ChemMedChem. 2007. PMID: 17407174

3

Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs.

Omkvist DH, Trangbæk DJ, Mildon J, Paine JS, Brodin B, Begtrup M, Nielsen CU. Omkvist DH, et al. Among authors: begtrup m. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13. Eur J Pharm Biopharm. 2011. PMID: 21147219

4

Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells.

Friedrichsen GM, Chen W, Begtrup M, Lee CP, Smith PL, Borchardt RT. Friedrichsen GM, et al. Among authors: begtrup m. Eur J Pharm Sci. 2002 Jul;16(1-2):1-13. doi: 10.1016/s0928-0987(02)00047-7. Eur J Pharm Sci. 2002. PMID: 12113886

5

Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: synthesis, stability and interaction with hPEPT1.

Eriksson AH, Elm PL, Begtrup M, Brodin B, Nielsen R, Steffansen B. Eriksson AH, et al. Among authors: begtrup m. Eur J Pharm Sci. 2005 May;25(1):145-54. doi: 10.1016/j.ejps.2005.02.007. Eur J Pharm Sci. 2005. PMID: 15854810

6

hPEPT1 affinity and translocation of selected Gln-Sar and Glu-Sar dipeptide derivatives.

Eriksson AH, Elm PL, Begtrup M, Nielsen R, Steffansen B, Brodin B. Eriksson AH, et al. Among authors: begtrup m. Mol Pharm. 2005 May-Jun;2(3):242-9. doi: 10.1021/mp050015+. Mol Pharm. 2005. PMID: 15934785

7

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1.

Andersen R, Nielsen CU, Begtrup M, Jørgensen FS, Brodin B, Frokjaer S, Steffansen B. Andersen R, et al. Among authors: begtrup m. Eur J Pharm Sci. 2006 Jul;28(4):325-35. doi: 10.1016/j.ejps.2006.03.007. Epub 2006 Mar 28. Eur J Pharm Sci. 2006. PMID: 16713701

8

Model prodrugs designed for the intestinal peptide transporter. A synthetic approach for coupling of hydroxy-containing compounds to dipeptides.

Friedrichsen GM, Nielsen CU, Steffansen B, Begtrup M. Friedrichsen GM, et al. Among authors: begtrup m. Eur J Pharm Sci. 2001 Aug;14(1):13-9. doi: 10.1016/s0928-0987(01)00137-3. Eur J Pharm Sci. 2001. PMID: 11457645

9

Application of enzymatically stable dipeptides for enhancement of intestinal permeability. Synthesis and in vitro evaluation of dipeptide-coupled compounds.

Friedrichsen GM, Jakobsen P, Taub M, Begtrup M. Friedrichsen GM, et al. Among authors: begtrup m. Bioorg Med Chem. 2001 Oct;9(10):2625-32. doi: 10.1016/s0968-0896(01)00066-9. Bioorg Med Chem. 2001. PMID: 11557350

10

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1.

Thorn K, Nielsen CU, Jakobsen P, Steffansen B, Zercher CK, Begtrup M. Thorn K, et al. Among authors: begtrup m. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4597-601. doi: 10.1016/j.bmcl.2011.05.108. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21703856 Free PMC article.

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