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Page 1
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.
Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmasheva N, Begnini F, Kiib AE, Dahlmann J, Chen C, Pavlou A, Poulsen TB, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch AKH, Pleschka S, Pessler F. Waqas FH, et al. Among authors: begnini f. PLoS Pathog. 2023 Jul 17;19(7):e1011506. doi: 10.1371/journal.ppat.1011506. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37459366 Free PMC article.
Correction to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction".
Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, Luttens A, Matricon P, Carlsson J, Lenders S, König B, Friedel A, Sjö P, Schiesser S, Kihlberg J. Begnini F, et al. J Med Chem. 2023 Feb 9;66(3):2204. doi: 10.1021/acs.jmedchem.3c00037. Epub 2023 Jan 26. J Med Chem. 2023. PMID: 36701206 Free PMC article. No abstract available.
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, Luttens A, Matricon P, Carlsson J, Lenders S, König B, Friedel A, Sjö P, Schiesser S, Kihlberg J. Begnini F, et al. J Med Chem. 2022 Feb 24;65(4):3473-3517. doi: 10.1021/acs.jmedchem.1c01975. Epub 2022 Feb 2. J Med Chem. 2022. PMID: 35108001 Free PMC article.
Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies.
Begnini F, Poongavanam V, Atilaw Y, Erdelyi M, Schiesser S, Kihlberg J. Begnini F, et al. ACS Med Chem Lett. 2021 May 18;12(6):983-990. doi: 10.1021/acsmedchemlett.1c00126. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34136079 Free PMC article.
Mining Natural Products for Macrocycles to Drug Difficult Targets.
Begnini F, Poongavanam V, Over B, Castaldo M, Geschwindner S, Johansson P, Tyagi M, Tyrchan C, Wissler L, Sjö P, Schiesser S, Kihlberg J. Begnini F, et al. J Med Chem. 2021 Jan 28;64(2):1054-1072. doi: 10.1021/acs.jmedchem.0c01569. Epub 2020 Dec 18. J Med Chem. 2021. PMID: 33337880 Free PMC article.
Drug Syntheses Beyond the Rule of 5.
Tyagi M, Begnini F, Poongavanam V, Doak BC, Kihlberg J. Tyagi M, et al. Among authors: begnini f. Chemistry. 2020 Jan 2;26(1):49-88. doi: 10.1002/chem.201902716. Epub 2019 Oct 11. Chemistry. 2020. PMID: 31483909 Review.