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Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
Sirinukunwattana K, Domingo E, Richman SD, Redmond KL, Blake A, Verrill C, Leedham SJ, Chatzipli A, Hardy C, Whalley CM, Wu CH, Beggs AD, McDermott U, Dunne PD, Meade A, Walker SM, Murray GI, Samuel L, Seymour M, Tomlinson I, Quirke P, Maughan T, Rittscher J, Koelzer VH; S:CORT consortium. Sirinukunwattana K, et al. Among authors: beggs ad. Gut. 2021 Mar;70(3):544-554. doi: 10.1136/gutjnl-2019-319866. Epub 2020 Jul 20. Gut. 2021. PMID: 32690604 Free PMC article.
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.
Jones AM, Beggs AD, Carvajal-Carmona L, Farrington S, Tenesa A, Walker M, Howarth K, Ballereau S, Hodgson SV, Zauber A, Bertagnolli M, Midgley R, Campbell H, Kerr D, Dunlop MG, Tomlinson IP. Jones AM, et al. Among authors: beggs ad. Gut. 2012 Feb;61(2):248-54. doi: 10.1136/gut.2011.239772. Epub 2011 Jun 27. Gut. 2012. PMID: 21708826 Free PMC article.
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.
Beggs AD, Domingo E, McGregor M, Presz M, Johnstone E, Midgley R, Kerr D, Oukrif D, Novelli M, Abulafi M, Hodgson SV, Fadhil W, Ilyas M, Tomlinson IP. Beggs AD, et al. Oncotarget. 2012 Nov;3(11):1348-55. doi: 10.18632/oncotarget.694. Oncotarget. 2012. PMID: 23154512 Free PMC article.
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.
Baker AM, Huang W, Wang XM, Jansen M, Ma XJ, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, Graham TA. Baker AM, et al. Among authors: beggs ad. Nat Commun. 2017 Dec 8;8(1):1998. doi: 10.1038/s41467-017-02295-5. Nat Commun. 2017. PMID: 29222441 Free PMC article.
165 results