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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: beerbaum m. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Opitz R, Müller M, Reuter C, Barone M, Soicke A, Roske Y, Piotukh K, Huy P, Beerbaum M, Wiesner B, Beyermann M, Schmieder P, Freund C, Volkmer R, Oschkinat H, Schmalz HG, Kühne R. Opitz R, et al. Among authors: beerbaum m. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6. doi: 10.1073/pnas.1422054112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848013 Free PMC article.
NMR structure of the Wnt modulator protein Sclerostin.
Weidauer SE, Schmieder P, Beerbaum M, Schmitz W, Oschkinat H, Mueller TD. Weidauer SE, et al. Among authors: beerbaum m. Biochem Biophys Res Commun. 2009 Feb 27;380(1):160-5. doi: 10.1016/j.bbrc.2009.01.062. Epub 2009 Jan 21. Biochem Biophys Res Commun. 2009. PMID: 19166819
Solid-phase synthesis of a cyclodepsipeptide: cotransin.
Coin I, Beerbaum M, Schmieder P, Bienert M, Beyermann M. Coin I, et al. Among authors: beerbaum m. Org Lett. 2008 Sep 4;10(17):3857-60. doi: 10.1021/ol800855p. Epub 2008 Jul 24. Org Lett. 2008. PMID: 18651745
14 results