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κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis.
Nat Commun. 2020 Jul 8;11(1):3409. doi: 10.1038/s41467-020-17226-0.
Nat Commun. 2020.
PMID: 32641778
Free PMC article.
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D.
Fitzian K, et al. Among authors: beel s.
Mol Cell. 2021 Jul 1;81(13):2705-2721.e8. doi: 10.1016/j.molcel.2021.04.019. Epub 2021 May 10.
Mol Cell. 2021.
PMID: 33974911
Free article.
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SorCS2 binds progranulin to regulate motor neuron development.
Thomasen PB, Salasova A, Kjaer-Sorensen K, Woloszczuková L, Lavický J, Login H, Tranberg-Jensen J, Almeida S, Beel S, Kavková M, Qvist P, Kjolby M, Ovesen PL, Nolte S, Vestergaard B, Udrea AC, Nejsum LN, Chao MV, Van Damme P, Krivanek J, Dasen J, Oxvig C, Nykjaer A.
Thomasen PB, et al. Among authors: beel s.
Cell Rep. 2023 Nov 28;42(11):113333. doi: 10.1016/j.celrep.2023.113333. Epub 2023 Oct 27.
Cell Rep. 2023.
PMID: 37897724
Free article.
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Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer.
Pethő Z, Najder K, Beel S, Fels B, Neumann I, Schimmelpfennig S, Sargin S, Wolters M, Grantins K, Wardelmann E, Mitkovski M, Oeckinghaus A, Schwab A.
Pethő Z, et al. Among authors: beel s.
JCI Insight. 2023 Oct 9;8(19):e170928. doi: 10.1172/jci.insight.170928.
JCI Insight. 2023.
PMID: 37643024
Free PMC article.
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Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits.
Beckers L, Geric I, Stroobants S, Beel S, Van Damme P, D'Hooge R, Baes M.
Beckers L, et al. Among authors: beel s.
J Neuroinflammation. 2019 Mar 13;16(1):61. doi: 10.1186/s12974-019-1442-3.
J Neuroinflammation. 2019.
PMID: 30866963
Free PMC article.
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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.
Beel S, Herdewyn S, Fazal R, De Decker M, Moisse M, Robberecht W, Van Den Bosch L, Van Damme P.
Beel S, et al.
Mol Neurodegener. 2018 Oct 16;13(1):55. doi: 10.1186/s13024-018-0288-y.
Mol Neurodegener. 2018.
PMID: 30326935
Free PMC article.
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Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
Beel S, et al.
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863. doi: 10.1093/hmg/ddx162.
Hum Mol Genet. 2017.
PMID: 28453791
Free PMC article.
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The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.
De Muynck L, Herdewyn S, Beel S, Scheveneels W, Van Den Bosch L, Robberecht W, Van Damme P.
De Muynck L, et al. Among authors: beel s.
Neurobiol Aging. 2013 Nov;34(11):2541-7. doi: 10.1016/j.neurobiolaging.2013.04.022. Epub 2013 May 24.
Neurobiol Aging. 2013.
PMID: 23706646
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