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Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.
McKeown L, Moss NK, Turner P, Li J, Heath N, Burke D, O'Regan D, Gilthorpe MS, Porter KE, Beech DJ. McKeown L, et al. Among authors: beech dj. Circ Res. 2012 Jun 22;111(1):66-76. doi: 10.1161/CIRCRESAHA.111.263616. Epub 2012 May 3. Circ Res. 2012. PMID: 22556336 Free PMC article.
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.
Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H. Akbulut Y, et al. Among authors: beech dj. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002/anie.201411511. Epub 2015 Feb 23. Angew Chem Int Ed Engl. 2015. PMID: 25707820 Free PMC article.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ. Li J, et al. Among authors: beech dj. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 26160956 Free PMC article.
Natural and synthetic flavonoid modulation of TRPC5 channels.
Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CW, Muraki K, Beech DJ, Bon RS. Naylor J, et al. Among authors: beech dj. Br J Pharmacol. 2016 Feb;173(3):562-74. doi: 10.1111/bph.13387. Epub 2016 Jan 13. Br J Pharmacol. 2016. PMID: 26565375 Free PMC article.
Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ. Webster PJ, et al. Among authors: beech dj. Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039. Oncotarget. 2017. PMID: 28178688 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. Among authors: beech dj. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: beech dj. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
256 results