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The giant diploid faba genome unlocks variation in a global protein crop.
Jayakodi M, Golicz AA, Kreplak J, Fechete LI, Angra D, Bednář P, Bornhofen E, Zhang H, Boussageon R, Kaur S, Cheung K, Čížková J, Gundlach H, Hallab A, Imbert B, Keeble-Gagnère G, Koblížková A, Kobrlová L, Krejčí P, Mouritzen TW, Neumann P, Nadzieja M, Nielsen LK, Novák P, Orabi J, Padmarasu S, Robertson-Shersby-Harvie T, Robledillo LÁ, Schiemann A, Tanskanen J, Törönen P, Warsame AO, Wittenberg AHJ, Himmelbach A, Aubert G, Courty PE, Doležel J, Holm LU, Janss LL, Khazaei H, Macas J, Mascher M, Smýkal P, Snowdon RJ, Stein N, Stoddard FL, Stougaard J, Tayeh N, Torres AM, Usadel B, Schubert I, O'Sullivan DM, Schulman AH, Andersen SU. Jayakodi M, et al. Among authors: bednar p. Nature. 2023 Mar;615(7953):652-659. doi: 10.1038/s41586-023-05791-5. Epub 2023 Mar 8. Nature. 2023. PMID: 36890232 Free PMC article.
Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease.
De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Girolamo SD, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Camilla Sammartino J, Giardina F, Gaiarsa S, Hammarström QP, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. De Gasparo R, et al. Among authors: bednar p. bioRxiv [Preprint]. 2021 Mar 5:2021.01.22.427567. doi: 10.1101/2021.01.22.427567. bioRxiv. 2021. PMID: 33501434 Free PMC article. Preprint.
JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
Dvorak Z, Vrzal R, Henklova P, Jancova P, Anzenbacherova E, Maurel P, Svecova L, Pavek P, Ehrmann J, Havlik R, Bednar P, Lemr K, Ulrichova J. Dvorak Z, et al. Among authors: bednar p. Biochem Pharmacol. 2008 Jan 15;75(2):580-8. doi: 10.1016/j.bcp.2007.09.013. Epub 2007 Sep 16. Biochem Pharmacol. 2008. PMID: 17959153
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