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Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. Byres E, et al. Among authors: beddoe t. Nature. 2008 Dec 4;456(7222):648-52. doi: 10.1038/nature07428. Epub 2008 Oct 29. Nature. 2008. PMID: 18971931 Free PMC article.
The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines.
Wang H, Paton JC, Herdman BP, Rogers TJ, Beddoe T, Paton AW. Wang H, et al. Among authors: beddoe t. Infect Immun. 2013 Mar;81(3):673-83. doi: 10.1128/IAI.01043-12. Epub 2012 Dec 17. Infect Immun. 2013. PMID: 23250951 Free PMC article.
Structural basis of subtilase cytotoxin SubAB assembly.
Le Nours J, Paton AW, Byres E, Troy S, Herdman BP, Johnson MD, Paton JC, Rossjohn J, Beddoe T. Le Nours J, et al. Among authors: beddoe t. J Biol Chem. 2013 Sep 20;288(38):27505-27516. doi: 10.1074/jbc.M113.462622. Epub 2013 Aug 6. J Biol Chem. 2013. PMID: 23921389 Free PMC article.
Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.
Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T. Littler DR, et al. Among authors: beddoe t. J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29. J Biol Chem. 2017. PMID: 28663369 Free PMC article.
Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases.
Vivian JP, Riedmaier P, Ge H, Le Nours J, Sansom FM, Wilce MC, Byres E, Dias M, Schmidberger JW, Cowan PJ, d'Apice AJ, Hartland EL, Rossjohn J, Beddoe T. Vivian JP, et al. Among authors: beddoe t. Structure. 2010 Feb 10;18(2):228-38. doi: 10.1016/j.str.2009.11.014. Structure. 2010. PMID: 20159467 Free article.
123 results