Becker-Pauly C - Search Results

1

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease.

Escrig A, Molinero A, Méndez B, Giralt M, Comes G, Sanchis P, Fernández-Gayol O, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J. Escrig A, et al. Cells. 2020 Jul 2;9(7):1605. doi: 10.3390/cells9071605. Cells. 2020. PMID: 32630818 Free PMC article.

2

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. Jefferson T, et al. Cell Mol Life Sci. 2013 Jan;70(2):309-33. doi: 10.1007/s00018-012-1106-2. Epub 2012 Sep 1. Cell Mol Life Sci. 2013. PMID: 22940918 Free PMC article.

3

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.

Becker-Pauly C, Rose-John S. Becker-Pauly C, et al. EMBO Mol Med. 2013 Jul;5(7):970-2. doi: 10.1002/emmm.201302899. Epub 2013 Jun 11. EMBO Mol Med. 2013. PMID: 23757215 Free PMC article. No abstract available.

4

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A. Schwarz J, et al. Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367. doi: 10.1016/j.bbamcr.2013.10.005. Epub 2013 Oct 14. Biochim Biophys Acta. 2013. PMID: 24135057 Free article.

5

The role of interleukin-6 signaling in nervous tissue.

Rothaug M, Becker-Pauly C, Rose-John S. Rothaug M, et al. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1218-27. doi: 10.1016/j.bbamcr.2016.03.018. Epub 2016 Mar 23. Biochim Biophys Acta. 2016. PMID: 27016501 Free article. Review.

6

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.

Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schäfers M, Holl R. Kalinin DV, et al. J Med Chem. 2016 Oct 27;59(20):9541-9559. doi: 10.1021/acs.jmedchem.6b01291. Epub 2016 Oct 13. J Med Chem. 2016. PMID: 27696839

7

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C. Arnold P, et al. Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053. Sci Rep. 2017. PMID: 28276471 Free PMC article.

8

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. Schmidt S, et al. J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22. J Exp Med. 2018. PMID: 29472497 Free PMC article.

9

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.

Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C. Sammel M, et al. Int J Mol Sci. 2019 Jul 26;20(15):3677. doi: 10.3390/ijms20153677. Int J Mol Sci. 2019. PMID: 31357561 Free PMC article.

10

Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.

Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Wichert R, et al. FASEB J. 2019 Nov;33(11):11925-11940. doi: 10.1096/fj.201801371R. Epub 2019 Aug 9. FASEB J. 2019. PMID: 31381863 Free PMC article.

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