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The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. Jefferson T, et al. Cell Mol Life Sci. 2013 Jan;70(2):309-33. doi: 10.1007/s00018-012-1106-2. Epub 2012 Sep 1. Cell Mol Life Sci. 2013. PMID: 22940918 Free PMC article.
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Broder C, Arnold P, Vadon-Le Goff S, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJ, Moali C, Becker-Pauly C. Broder C, et al. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14219-24. doi: 10.1073/pnas.1305464110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940311 Free PMC article.
104 results