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Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens.
Karamatic Crew V, Tilley LA, Satchwell TJ, AlSubhi SA, Jones B, Spring FA, Walser PJ, Martins Freire C, Murciano N, Rotordam MG, Woestmann SJ, Hamed M, Alradwan R, AlKhrousey M, Skidmore I, Lewis S, Hussain S, Jackson J, Latham T, Kilby MD, Lester W, Becker N, Rapedius M, Toye AM, Thornton NM. Karamatic Crew V, et al. Among authors: becker n. Blood. 2023 Jan 12;141(2):135-146. doi: 10.1182/blood.2022016504. Blood. 2023. PMID: 36122374 Free PMC article.
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery.
Obergrussberger A, Goetze TA, Brinkwirth N, Becker N, Friis S, Rapedius M, Haarmann C, Rinke-Weiß I, Stölzle-Feix S, Brüggemann A, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Expert Opin Drug Discov. 2018 Mar;13(3):269-277. doi: 10.1080/17460441.2018.1428555. Epub 2018 Jan 17. Expert Opin Drug Discov. 2018. PMID: 29343120 Review.
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.
Han X, Samieegohar M, Ridder BJ, Wu WW, Randolph A, Tran P, Sheng J, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Strauss DG, Li Z. Han X, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2020 Sep;105:106890. doi: 10.1016/j.vascn.2020.106890. Epub 2020 Jun 21. J Pharmacol Toxicol Methods. 2020. PMID: 32574700 Free article.
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
Rotordam MG, Obergrussberger A, Brinkwirth N, Takasuna K, Becker N, Horváth A, Goetze TA, Rapedius M, Furukawa H, Hasegawa Y, Oka T, Fertig N, Stoelzle-Feix S. Rotordam MG, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107125. doi: 10.1016/j.vascn.2021.107125. Epub 2021 Sep 6. J Pharmacol Toxicol Methods. 2021. PMID: 34500078
The suitability of high throughput automated patch clamp for physiological applications.
Obergrussberger A, Rinke-Weiß I, Goetze TA, Rapedius M, Brinkwirth N, Becker N, Rotordam MG, Hutchison L, Madau P, Pau D, Dalrymple D, Braun N, Friis S, Pless SA, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Physiol. 2022 Jan;600(2):277-297. doi: 10.1113/JP282107. Epub 2021 Oct 8. J Physiol. 2022. PMID: 34555195 Free article.
Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer.
Flormann D, Qiao M, Murciano N, Iacono G, Darras A, Hof S, Recktenwald SM, Rotordam MG, Becker N, Geisel J, Wagner C, von Lindern M, van den Akker E, Kaestner L. Flormann D, et al. Among authors: becker n. Am J Hematol. 2022 May;97(5):E180-E183. doi: 10.1002/ajh.26509. Epub 2022 Feb 25. Am J Hematol. 2022. PMID: 35179248 Free article. No abstract available.
Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: becker n. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells.
Hatem A, Esperti S, Murciano N, Qiao M, Giustina Rotordam M, Becker N, Nader E, Maurer F, Pérès L, Bouyer G, Kaestner L, Connes P, Egée S. Hatem A, et al. Among authors: becker n. Am J Hematol. 2023 Dec;98(12):E383-E386. doi: 10.1002/ajh.27109. Epub 2023 Oct 6. Am J Hematol. 2023. PMID: 37800361
1,053 results