Becker HF - Search Results

1

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis.

Djaout K, Singh V, Boum Y, Katawera V, Becker HF, Bush NG, Hearnshaw SJ, Pritchard JE, Bourbon P, Madrid PB, Maxwell A, Mizrahi V, Myllykallio H, Ekins S. Djaout K, et al. Among authors: becker hf. Sci Rep. 2016 Jun 10;6:27792. doi: 10.1038/srep27792. Sci Rep. 2016. PMID: 27283217 Free PMC article.

2

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.

Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. Basta T, et al. Among authors: becker hf. Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120. Open Biol. 2012. PMID: 23155486 Free PMC article.

3

Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.

Becker HF, Djaout K, Lamarre I, Ulmer JE, Schaming D, Balland V, Liebl U, Myllykallio H, Vos MH. Becker HF, et al. Biochem J. 2014 Apr 1;459(1):37-45. doi: 10.1042/BJ20131567. Biochem J. 2014. PMID: 24422556

4

High-throughput sequencing reveals circular substrates for an archaeal RNA ligase.

Becker HF, Héliou A, Djaout K, Lestini R, Regnier M, Myllykallio H. Becker HF, et al. RNA Biol. 2017 Aug 3;14(8):1075-1085. doi: 10.1080/15476286.2017.1302640. Epub 2017 Mar 9. RNA Biol. 2017. PMID: 28277897 Free PMC article.

5

Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile.

Abu El Asrar R, Margamuljana L, Klaassen H, Nijs M, Marchand A, Chaltin P, Myllykallio H, Becker HF, De Jonghe S, Herdewijn P, Lescrinier E. Abu El Asrar R, et al. Among authors: becker hf. Biochem Pharmacol. 2017 Jul 1;135:69-78. doi: 10.1016/j.bcp.2017.03.017. Epub 2017 Mar 28. Biochem Pharmacol. 2017. PMID: 28359706

6

Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X.

Modranka J, Li J, Parchina A, Vanmeert M, Dumbre S, Salman M, Myllykallio H, Becker HF, Vanhoutte R, Margamuljana L, Nguyen H, Abu El-Asrar R, Rozenski J, Herdewijn P, De Jonghe S, Lescrinier E. Modranka J, et al. Among authors: becker hf. ChemMedChem. 2019 Mar 22;14(6):645-662. doi: 10.1002/cmdc.201800739. Epub 2019 Feb 20. ChemMedChem. 2019. PMID: 30702807

7

Diversity of circular RNAs and RNA ligases in archaeal cells.

Becker HF, L'Hermitte-Stead C, Myllykallio H. Becker HF, et al. Biochimie. 2019 Sep;164:37-44. doi: 10.1016/j.biochi.2019.06.011. Epub 2019 Jun 15. Biochimie. 2019. PMID: 31212038

8

Mechanism of Naphthoquinone Selectivity of Thymidylate Synthase ThyX.

Myllykallio H, Becker HF, Aleksandrov A. Myllykallio H, et al. Among authors: becker hf. Biophys J. 2020 Dec 15;119(12):2508-2516. doi: 10.1016/j.bpj.2020.10.042. Epub 2020 Nov 18. Biophys J. 2020. PMID: 33217379 Free PMC article.

9

Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.

Biteau NG, Roy V, Lambry JC, Becker HF, Myllykallio H, Agrofoglio LA. Biteau NG, et al. Among authors: becker hf. Bioorg Med Chem. 2021 Sep 15;46:116351. doi: 10.1016/j.bmc.2021.116351. Epub 2021 Aug 6. Bioorg Med Chem. 2021. PMID: 34391120

10

Synthesis and Structure-Activity Relationship Studies of Pyrido [1,2-e]Purine-2,4(1H,3H)-Dione Derivatives Targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis.

Biteau NG, Roy V, Nicolas C, Becker HF, Lambry JC, Myllykallio H, Agrofoglio LA. Biteau NG, et al. Among authors: becker hf. Molecules. 2022 Sep 21;27(19):6216. doi: 10.3390/molecules27196216. Molecules. 2022. PMID: 36234754 Free PMC article.

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