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IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption.
Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, Schmid B, Skottke L, Lee S, Jeon NL, Wohlfahrt T, Kramer V, Tripal P, Schumann M, Kersting S, Handtrack C, Geppert CI, Suchowski K, Adams RH, Becker C, Ramming A, Naschberger E, Britzen-Laurent N, Stürzl M. Langer V, et al. Among authors: becker c. J Clin Invest. 2019 Nov 1;129(11):4691-4707. doi: 10.1172/JCI124884. J Clin Invest. 2019. PMID: 31566580 Free PMC article. Clinical Trial.
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF. Mudter J, et al. Among authors: becker c. J Clin Invest. 2008 Jul;118(7):2415-26. doi: 10.1172/JCI33227. J Clin Invest. 2008. PMID: 18535667 Free PMC article.
Smad7 expression in T cells prevents colitis-associated cancer.
Rizzo A, Waldner MJ, Stolfi C, Sarra M, Fina D, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G, Fantini MC. Rizzo A, et al. Among authors: becker c. Cancer Res. 2011 Dec 15;71(24):7423-32. doi: 10.1158/0008-5472.CAN-11-1895. Epub 2011 Oct 25. Cancer Res. 2011. PMID: 22028324
3,990 results