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Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.
Überbacher C, Obergasteiger J, Volta M, Venezia S, Müller S, Pesce I, Pizzi S, Lamonaca G, Picard A, Cattelan G, Malpeli G, Zoli M, Beccano-Kelly D, Flynn R, Wade-Martins R, Pramstaller PP, Hicks AA, Cowley SA, Corti C. Überbacher C, et al. Among authors: beccano kelly d. Stem Cell Res. 2019 Dec;41:101656. doi: 10.1016/j.scr.2019.101656. Epub 2019 Nov 9. Stem Cell Res. 2019. PMID: 31733438 Free PMC article.
Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B. Benkert J, et al. Among authors: beccano kelly d. Nat Commun. 2019 Nov 8;10(1):5094. doi: 10.1038/s41467-019-12834-x. Nat Commun. 2019. PMID: 31704946 Free PMC article.
Impaired dopamine release in Parkinson's disease.
Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R. Cramb KML, et al. Among authors: beccano kelly d. Brain. 2023 Aug 1;146(8):3117-3132. doi: 10.1093/brain/awad064. Brain. 2023. PMID: 36864664 Free PMC article. Review.
Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R. Beccano-Kelly DA, et al. iScience. 2023 Jun 7;26(7):107044. doi: 10.1016/j.isci.2023.107044. eCollection 2023 Jul 21. iScience. 2023. PMID: 37426342 Free PMC article.
Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.
Volta M, Beccano-Kelly DA, Paschall SA, Cataldi S, MacIsaac SE, Kuhlmann N, Kadgien CA, Tatarnikov I, Fox J, Khinda J, Mitchell E, Bergeron S, Melrose H, Farrer MJ, Milnerwood AJ. Volta M, et al. Among authors: beccano kelly da. Elife. 2017 Sep 20;6:e28377. doi: 10.7554/eLife.28377. Elife. 2017. PMID: 28930069 Free PMC article.
20 results