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JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.
Becattini B, Zani F, Breasson L, Sardi C, D'Agostino VG, Choo MK, Provenzani A, Park JM, Solinas G. Becattini B, et al. FASEB J. 2016 Sep;30(9):3124-32. doi: 10.1096/fj.201600393R. Epub 2016 May 26. FASEB J. 2016. PMID: 27230858 Free PMC article.
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.-Becattini, B., Zani, F., Breasson, L., Sardi, C., D'Agostino, V. G., Choo, M....
We conclude that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most e …
PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.
Breasson L, Sardi C, Becattini B, Zani F, Solinas G. Breasson L, et al. Among authors: becattini b. FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13. FASEB J. 2018. PMID: 28904022
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects on insulin secretion.-Breasson, L., Sardi, C., Becattini, B., Zani, F., Solinas, G. PI3Kgamma ablation does not promote diabet …
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects …
PI3K and AKT at the Interface of Signaling and Metabolism.
Solinas G, Becattini B. Solinas G, et al. Among authors: becattini b. Curr Top Microbiol Immunol. 2022;436:311-336. doi: 10.1007/978-3-031-06566-8_13. Curr Top Microbiol Immunol. 2022. PMID: 36243850
27 results