Beavers MP - Search Results

1

Almagro JC, Beavers MP, Hernandez-Guzman F, Maier J, Shaulsky J, Butenhof K, Labute P, Thorsteinson N, Kelly K, Teplyakov A, Luo J, Sweet R, Gilliland GL. Almagro JC, et al. Among authors: beavers mp. Proteins. 2011 Nov;79(11):3050-66. doi: 10.1002/prot.23130. Epub 2011 Sep 21. Proteins. 2011. PMID: 21935986

2

The total synthesis of roquefortine C and a rationale for the thermodynamic stability of isoroquefortine C over roquefortine C.

Shangguan N, Hehre WJ, Ohlinger WS, Beavers MP, Joullié MM. Shangguan N, et al. Among authors: beavers mp. J Am Chem Soc. 2008 May 14;130(19):6281-7. doi: 10.1021/ja800067q. Epub 2008 Apr 16. J Am Chem Soc. 2008. PMID: 18412344

3

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL. Shah PP, et al. Among authors: beavers mp. Mol Pharmacol. 2008 Jul;74(1):34-41. doi: 10.1124/mol.108.046219. Epub 2008 Apr 10. Mol Pharmacol. 2008. PMID: 18403718 Free PMC article.

4

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. Miller MW, et al. Among authors: beavers mp. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24. doi: 10.1073/pnas.0811622106. Epub 2009 Jan 13. Proc Natl Acad Sci U S A. 2009. PMID: 19141632 Free PMC article.

5

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Myers MC, Shah PP, Beavers MP, Napper AD, Diamond SL, Smith AB 3rd, Huryn DM. Myers MC, et al. Among authors: beavers mp. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3646-51. doi: 10.1016/j.bmcl.2008.04.065. Epub 2008 May 1. Bioorg Med Chem Lett. 2008. PMID: 18499453 Free PMC article.

6

Molecular docking of cathepsin L inhibitors in the binding site of papain.

Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB 3rd. Beavers MP, et al. J Chem Inf Model. 2008 Jul;48(7):1464-72. doi: 10.1021/ci800085c. Epub 2008 Jul 4. J Chem Inf Model. 2008. PMID: 18598021 Free PMC article.

7

Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.

Liu Z, Myers MC, Shah PP, Beavers MP, Benedetti PA, Diamond SL, Smith AB 3rd, Huryn DM. Liu Z, et al. Among authors: beavers mp. Comb Chem High Throughput Screen. 2010 May;13(4):337-51. doi: 10.2174/138620710791054303. Comb Chem High Throughput Screen. 2010. PMID: 20438448 Free PMC article.

8

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.

Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB 3rd. Myers MC, et al. Among authors: beavers mp. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4761-6. doi: 10.1016/j.bmcl.2007.06.091. Epub 2007 Jul 5. Bioorg Med Chem Lett. 2007. PMID: 17656088 Free PMC article.

9

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

Kuo GH, Prouty C, DeAngelis A, Shen L, O'Neill DJ, Shah C, Connolly PJ, Murray WV, Conway BR, Cheung P, Westover L, Xu JZ, Look RA, Demarest KT, Emanuel S, Middleton SA, Jolliffe L, Beavers MP, Chen X. Kuo GH, et al. Among authors: beavers mp. J Med Chem. 2003 Sep 11;46(19):4021-31. doi: 10.1021/jm030115o. J Med Chem. 2003. PMID: 12954055

10

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Thurmond RL, Beavers MP, Cai H, Meduna SP, Gustin DJ, Sun S, Almond HJ, Karlsson L, Edwards JP. Thurmond RL, et al. Among authors: beavers mp. J Med Chem. 2004 Sep 23;47(20):4799-801. doi: 10.1021/jm0496133. J Med Chem. 2004. PMID: 15369380

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