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464 results

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Page 1
The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.
Labroli MA, Dwyer MP, Shen R, Popovici-Muller J, Pu Q, Wyss D, McCoy M, Barrett D, Davis N, Seghezzi W, Shanahan F, Taricani L, Beaumont M, Malinao MC, Parry D, Guzi TJ. Labroli MA, et al. Among authors: beaumont m. Bioorg Med Chem. 2014 Apr 1;22(7):2303-10. doi: 10.1016/j.bmc.2014.02.007. Epub 2014 Feb 15. Bioorg Med Chem. 2014. PMID: 24588962
Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma.
Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M. Louten J, et al. Among authors: beaumont m. Biomark Insights. 2012;7:87-104. doi: 10.4137/BMI.S9776. Epub 2012 Jul 10. Biomark Insights. 2012. PMID: 22837640 Free PMC article.
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.
Cayatte C, Joyce-Shaikh B, Vega F, Boniface K, Grein J, Murphy E, Blumenschein WM, Chen S, Malinao MC, Basham B, Pierce RH, Bowman EP, McKenzie BS, Elson CO, Faubion WA, Malefyt Rde W, Kastelein RA, Cua D, McClanahan TK, Beaumont M. Cayatte C, et al. Among authors: beaumont m. Clin Transl Gastroenterol. 2012 Feb 16;3(2):e10. doi: 10.1038/ctg.2012.2. Clin Transl Gastroenterol. 2012. PMID: 23238132 Free PMC article.
Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies.
Zhang Q, Spellman DS, Song Y, Choi B, Hatcher NG, Tomazela D, Beaumont M, Tabrizifard M, Prabhavalkar D, Seghezzi W, Harrelson J, Bateman KP. Zhang Q, et al. Among authors: beaumont m. Anal Chem. 2014 Sep 2;86(17):8776-84. doi: 10.1021/ac5019827. Epub 2014 Aug 14. Anal Chem. 2014. PMID: 25010922
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.
Orth P, Xiao L, Hernandez LD, Reichert P, Sheth PR, Beaumont M, Yang X, Murgolo N, Ermakov G, DiNunzio E, Racine F, Karczewski J, Secore S, Ingram RN, Mayhood T, Strickland C, Therien AG. Orth P, et al. Among authors: beaumont m. J Biol Chem. 2014 Jun 27;289(26):18008-21. doi: 10.1074/jbc.M114.560748. Epub 2014 May 12. J Biol Chem. 2014. PMID: 24821719 Free PMC article.
Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α.
Mak VW, Patel AM, Yen R, Hanisak J, Lim YH, Bao J, Zheng R, Seganish WM, Yu Y, Healy DR, Ogawa A, Ren Z, Soriano A, Ermakov GP, Beaumont M, Metwally E, Cheng AC, Verras A, Fischmann T, Zebisch M, Silvestre HL, McEwan PA, Barker J, Rearden P, Greshock TJ. Mak VW, et al. Among authors: beaumont m. J Med Chem. 2022 Aug 11;65(15):10318-10340. doi: 10.1021/acs.jmedchem.1c02109. Epub 2022 Jul 25. J Med Chem. 2022. PMID: 35878399
Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo.
Yang X, Wang F, Zhang Y, Wang L, Antonenko S, Zhang S, Zhang YW, Tabrizifard M, Ermakov G, Wiswell D, Beaumont M, Liu L, Richardson D, Shameem M, Ambrogelly A. Yang X, et al. Among authors: beaumont m. J Pharm Sci. 2015 Dec;104(12):4002-4014. doi: 10.1002/jps.24620. Epub 2015 Aug 26. J Pharm Sci. 2015. PMID: 26308749
464 results