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Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines.
Tregoning JS, Stirling DC, Wang Z, Flight KE, Brown JC, Blakney AK, McKay PF, Cunliffe RF, Murugaiah V, Fox CB, Beattie M, Tam YK, Johansson C, Shattock RJ. Tregoning JS, et al. Among authors: beattie m. Mol Ther Nucleic Acids. 2022 Dec 5;31:29-42. doi: 10.1016/j.omtn.2022.11.024. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2022. PMID: 36589712 Free PMC article.
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA.
Villiger L, Rothgangl T, Witzigmann D, Oka R, Lin PJC, Qi W, Janjuha S, Berk C, Ringnalda F, Beattie MB, Stoffel M, Thöny B, Hall J, Rehrauer H, van Boxtel R, Tam YK, Schwank G. Villiger L, et al. Among authors: beattie mb. Nat Biomed Eng. 2021 Feb;5(2):179-189. doi: 10.1038/s41551-020-00671-z. Epub 2021 Jan 25. Nat Biomed Eng. 2021. PMID: 33495639 Free PMC article.
Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses.
McMahon M, O'Dell G, Tan J, Sárközy A, Vadovics M, Carreño JM, Puente-Massaguer E, Muramatsu H, Bajusz C, Rijnink W, Beattie M, Tam YK, Kirkpatrick Roubidoux E, Francisco I, Strohmeier S, Kanekiyo M, Graham BS, Krammer F, Pardi N. McMahon M, et al. Among authors: beattie m. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2206333119. doi: 10.1073/pnas.2206333119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322769 Free PMC article.
A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1.
Egan KP, Awasthi S, Tebaldi G, Hook LM, Naughton AM, Fowler BT, Beattie M, Alameh MG, Weissman D, Cohen GH, Friedman HM. Egan KP, et al. Among authors: beattie m. Viruses. 2023 Jun 30;15(7):1483. doi: 10.3390/v15071483. Viruses. 2023. PMID: 37515169 Free PMC article.
A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets.
van de Ven K, Lanfermeijer J, van Dijken H, Muramatsu H, Vilas Boas de Melo C, Lenz S, Peters F, Beattie MB, Lin PJC, Ferreira JA, van den Brand J, van Baarle D, Pardi N, de Jonge J. van de Ven K, et al. Sci Adv. 2022 Dec 14;8(50):eadc9937. doi: 10.1126/sciadv.adc9937. Epub 2022 Dec 14. Sci Adv. 2022. PMID: 36516261 Free PMC article.
539 results