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Rescue of glutaric aciduria type I in mice by liver-directed therapies.
Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KD. Barzi M, et al. Among authors: beasley j. Sci Transl Med. 2023 Apr 19;15(692):eadf4086. doi: 10.1126/scitranslmed.adf4086. Epub 2023 Apr 19. Sci Transl Med. 2023. PMID: 37075130 Free PMC article.
Comparison of dermatan sulfate and heparan sulfate concentrations in serum, cerebrospinal fluid and urine in patients with mucopolysaccharidosis type I receiving intravenous and intrathecal enzyme replacement therapy.
Zhang H, Dickson PI, Stiles AR, Chen AH, Le SQ, McCaw P, Beasley J, Millington DS, Young SP. Zhang H, et al. Among authors: beasley j. Clin Chim Acta. 2020 Sep;508:179-184. doi: 10.1016/j.cca.2020.05.035. Epub 2020 May 20. Clin Chim Acta. 2020. PMID: 32442432
Multidimensional predictors of antidepressant responses: Integrating mitochondrial, genetic, metabolic and environmental factors with clinical outcomes.
Nasca C, Barnhill O, DeAngelis P, Watson K, Lin J, Beasley J, Young SP, Myoraku A, Dobbin J, Bigio B, McEwen B, Rasgon N. Nasca C, et al. Among authors: beasley j. Neurobiol Stress. 2021 Oct 9;15:100407. doi: 10.1016/j.ynstr.2021.100407. eCollection 2021 Nov. Neurobiol Stress. 2021. PMID: 34815985 Free PMC article.
Acetyl-l-carnitine deficiency in patients with major depressive disorder.
Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, Beasley J, Millington DS, Mathé AA, Kocsis JH, Murrough JW, McEwen BS, Rasgon N. Nasca C, et al. Among authors: beasley j. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632. doi: 10.1073/pnas.1801609115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061399 Free PMC article. Clinical Trial.
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.
Xu L, Yin Y, Li Y, Chen X, Chang Y, Zhang H, Liu J, Beasley J, McCaw P, Zhang H, Young S, Groth J, Wang Q, Locasale JW, Gao X, Tang DG, Dong X, He Y, George D, Hu H, Huang J. Xu L, et al. Among authors: beasley j. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2012748118. doi: 10.1073/pnas.2012748118. Proc Natl Acad Sci U S A. 2021. PMID: 33753479 Free PMC article.
Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web Tool for Triaging Compounds with Undesired Pharmacokinetics Profiles.
Rath M, Wellnitz J, Martin HJ, Melo-Filho C, Hochuli JE, Silva GM, Beasley JM, Travis M, Sessions ZL, Popov KI, Zakharov AV, Cherkasov A, Alves V, Muratov EN, Tropsha A. Rath M, et al. Among authors: beasley jm. J Med Chem. 2024 Apr 25;67(8):6508-6518. doi: 10.1021/acs.jmedchem.3c02446. Epub 2024 Apr 3. J Med Chem. 2024. PMID: 38568752
563 results