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Page 1
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
Van Eeckhoutte HP, Donovan C, Kim RY, Conlon TM, Ansari M, Khan H, Jayaraman R, Hansbro NG, Dondelinger Y, Delanghe T, Beal AM, Geddes B, Bertin J, Vanden Berghe T, De Volder J, Maes T, Vandenabeele P, Vanaudenaerde BM, Deforce D, Škevin S, Van Nieuwerburgh F, Verhamme FM, Joos GF, Idrees S, Schiller HB, Yildirim AÖ, Faiz A, Bertrand MJM, Brusselle GG, Hansbro PM, Bracke KR. Van Eeckhoutte HP, et al. Among authors: beal am. Eur Respir J. 2023 Apr 1;61(4):2201506. doi: 10.1183/13993003.01506-2022. Print 2023 Apr. Eur Respir J. 2023. PMID: 36549711
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Garcia LR, Tenev T, Newman R, Haich RO, Liccardi G, John SW, Annibaldi A, Yu L, Pardo M, Young SN, Fitzgibbon C, Fernando W, Guppy N, Kim H, Liang LY, Lucet IS, Kueh A, Roxanis I, Gazinska P, Sims M, Smyth T, Ward G, Bertin J, Beal AM, Geddes B, Choudhary JS, Murphy JM, Aurelia Ball K, Upton JW, Meier P. Garcia LR, et al. Among authors: beal am. Nat Commun. 2021 Jun 7;12(1):3364. doi: 10.1038/s41467-021-23474-5. Nat Commun. 2021. PMID: 34099649 Free PMC article.
An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols K, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MRM, Cadwell K. Matsuzawa-Ishimoto Y, et al. Blood. 2020 Jun 25;135(26):2388-2401. doi: 10.1182/blood.2019004116. Blood. 2020. PMID: 32232483 Free PMC article.
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, Rieser E, Fisher A, Hutchinson C, Taraborrelli L, Hartwig T, Lafont E, Haas TL, Shimizu Y, Böiers C, Sarr A, Rickard J, Alvarez-Diaz S, Ashworth MT, Beal A, Enver T, Bertin J, Kaiser W, Strasser A, Silke J, Bouillet P, Walczak H. Peltzer N, et al. Nature. 2018 May;557(7703):112-117. doi: 10.1038/s41586-018-0064-8. Epub 2018 Apr 25. Nature. 2018. PMID: 29695863 Free PMC article.
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den Brink MRM, Cadwell K. Matsuzawa-Ishimoto Y, et al. J Exp Med. 2017 Dec 4;214(12):3687-3705. doi: 10.1084/jem.20170558. Epub 2017 Oct 31. J Exp Med. 2017. PMID: 29089374 Free PMC article.
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, Gutierrez J, Diskin B, Hundeyin M, Reilly M, Lich JD, Harris PA, Mahajan MK, Thorpe JH, Nassau P, Mosley JE, Leinwand J, Kochen Rossi JA, Mishra A, Aykut B, Glacken M, Ochi A, Verma N, Kim JI, Vasudevaraja V, Adeegbe D, Almonte C, Bagdatlioglu E, Cohen DJ, Wong KK, Bertin J, Miller G. Wang W, et al. Among authors: beal am. Cancer Cell. 2018 Nov 12;34(5):757-774.e7. doi: 10.1016/j.ccell.2018.10.006. Cancer Cell. 2018. PMID: 30423296 Free PMC article.
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.
Yu JW, Hoffman S, Beal AM, Dykon A, Ringenberg MA, Hughes AC, Dare L, Anderson AD, Finger J, Kasparcova V, Rickard D, Berger SB, Ramanjulu J, Emery JG, Gough PJ, Bertin J, Foley KP. Yu JW, et al. Among authors: beal am. PLoS One. 2015 May 12;10(5):e0127083. doi: 10.1371/journal.pone.0127083. eCollection 2015. PLoS One. 2015. PMID: 25965667 Free PMC article.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW. Harris PA, et al. Among authors: beal am. J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2. J Med Chem. 2019. PMID: 31013427
69 results