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Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.
Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI. Arlia-Ciommo A, et al. Among authors: beach a. Oncotarget. 2018 Oct 9;9(79):34945-34971. doi: 10.18632/oncotarget.26188. eCollection 2018 Oct 9. Oncotarget. 2018. PMID: 30405886 Free PMC article.
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI. Goldberg AA, et al. Among authors: beach a. Aging (Albany NY). 2010 Jul;2(7):393-414. doi: 10.18632/aging.100168. Aging (Albany NY). 2010. PMID: 20622262 Free PMC article.
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.
Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI. Arlia-Ciommo A, et al. Among authors: beach a. Oncotarget. 2018 Mar 5;9(22):16163-16184. doi: 10.18632/oncotarget.24604. eCollection 2018 Mar 23. Oncotarget. 2018. PMID: 29662634 Free PMC article.
Effect of calorie restriction on the metabolic history of chronologically aging yeast.
Goldberg AA, Bourque SD, Kyryakov P, Gregg C, Boukh-Viner T, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Cyr D, Milijevic S, Titorenko VI. Goldberg AA, et al. Among authors: beach a. Exp Gerontol. 2009 Sep;44(9):555-71. doi: 10.1016/j.exger.2009.06.001. Epub 2009 Jun 17. Exp Gerontol. 2009. PMID: 19539741
A novel function of lipid droplets in regulating longevity.
Goldberg AA, Bourque SD, Kyryakov P, Boukh-Viner T, Gregg C, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Titorenko VI. Goldberg AA, et al. Among authors: beach a. Biochem Soc Trans. 2009 Oct;37(Pt 5):1050-5. doi: 10.1042/BST0371050. Biochem Soc Trans. 2009. PMID: 19754450
Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.
Burstein MT, Beach A, Richard VR, Koupaki O, Gomez-Perez A, Goldberg AA, Kyryakov P, Bourque SD, Glebov A, Titorenko VI. Burstein MT, et al. Among authors: beach a. Dose Response. 2012;10(1):75-82. doi: 10.2203/dose-response.11-011.Titorenko. Epub 2011 Jul 27. Dose Response. 2012. PMID: 22423230 Free PMC article.
98 results