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A microbiome-dependent gut-brain pathway regulates motivation for exercise.
Dohnalová L, Lundgren P, Carty JRE, Goldstein N, Wenski SL, Nanudorn P, Thiengmag S, Huang KP, Litichevskiy L, Descamps HC, Chellappa K, Glassman A, Kessler S, Kim J, Cox TO, Dmitrieva-Posocco O, Wong AC, Allman EL, Ghosh S, Sharma N, Sengupta K, Cornes B, Dean N, Churchill GA, Khurana TS, Sellmyer MA, FitzGerald GA, Patterson AD, Baur JA, Alhadeff AL, Helfrich EJN, Levy M, Betley JN, Thaiss CA. Dohnalová L, et al. Among authors: baur ja. Nature. 2022 Dec;612(7941):739-747. doi: 10.1038/s41586-022-05525-z. Epub 2022 Dec 14. Nature. 2022. PMID: 36517598
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Frederick DW, et al. Among authors: baur ja. Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005. Cell Metab. 2016. PMID: 27508874 Free PMC article.
Hypothalamic mTORC2 is essential for metabolic health and longevity.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW. Chellappa K, et al. Among authors: baur ja. Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1. Aging Cell. 2019. PMID: 31373126 Free PMC article.
mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.
Paolella LM, Mukherjee S, Tran CM, Bellaver B, Hugo M, Luongo TS, Shewale SV, Lu W, Chellappa K, Baur JA. Paolella LM, et al. Among authors: baur ja. Mol Metab. 2020 Feb;32:136-147. doi: 10.1016/j.molmet.2019.12.003. Epub 2019 Dec 13. Mol Metab. 2020. PMID: 32029223 Free PMC article.
138 results