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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Dodd CJ, Chronister KS, Rathnayake U, Parr LC, Li K, Chang S, Mi D, Days EL, Bauer JA, Cho HP, Boutaud O, Denton JS, Lindsley CW, Han C. Dodd CJ, et al. Among authors: bauer ja. Bioorg Med Chem Lett. 2023 May 1;87:129256. doi: 10.1016/j.bmcl.2023.129256. Epub 2023 Mar 24. Bioorg Med Chem Lett. 2023. PMID: 36966977 Free PMC article.
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Lyon M, Li P, Ferreira JJ, Lazarenko RM, Kharade SV, Kramer M, McClenahan SJ, Days E, Bauer JA, Spitznagel BD, Weaver CD, Borrego Alvarez A, Puga Molina LC, Lybaert P, Khambekar S, Liu A, Lindsley CW, Denton J, Santi CM. Lyon M, et al. Among authors: bauer ja. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212338120. doi: 10.1073/pnas.2212338120. Epub 2023 Jan 17. Proc Natl Acad Sci U S A. 2023. PMID: 36649421 Free PMC article.
Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Kunová N, Ondrovičová G, Bauer JA, Krajčovičová V, Pinkas M, Stojkovičová B, Havalová H, Lukáčová V, Kohútová L, Košťan J, Martináková L, Baráth P, Nováček J, Zoll S, Kereϊche S, Kutejová E, Pevala V. Kunová N, et al. Among authors: bauer ja. Sci Rep. 2024 Apr 30;14(1):9923. doi: 10.1038/s41598-024-60030-9. Sci Rep. 2024. PMID: 38688959 Free PMC article.
284 results