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Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.
Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, König C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Müller R. Kling A, et al. Among authors: bauer a. Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690. Science. 2015. PMID: 26045430
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.
Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: bauer a. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.
Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V. Nazaré M, et al. Among authors: bauer a. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):905-11. doi: 10.1002/anie.201107091. Epub 2011 Dec 21. Angew Chem Int Ed Engl. 2012. PMID: 22190348 No abstract available.
Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
Couturier C, Silve S, Morales R, Pessegue B, Llopart S, Nair A, Bauer A, Scheiper B, Pöverlein C, Ganzhorn A, Lagrange S, Bacqué E. Couturier C, et al. Among authors: bauer a. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1455-9. doi: 10.1016/j.bmcl.2015.02.035. Epub 2015 Feb 23. Bioorg Med Chem Lett. 2015. PMID: 25770781
Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties.
Hoffmann H, Kogler H, Heyse W, Matter H, Caspers M, Schummer D, Klemke-Jahn C, Bauer A, Penarier G, Debussche L, Brönstrup M. Hoffmann H, et al. Among authors: bauer a. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10145-8. doi: 10.1002/anie.201411377. Epub 2015 Jun 1. Angew Chem Int Ed Engl. 2015. PMID: 26031409
Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity.
Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, Schummer D, Toti L, Wink J, Müller R. Fu C, et al. Among authors: bauer a. J Am Chem Soc. 2015 Jun 24;137(24):7692-705. doi: 10.1021/jacs.5b01794. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26043159
2,962 results