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Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Frye SV, Haffner CD, Maloney PR, Hiner RN, Dorsey GF, Noe RA, Unwalla RJ, Batchelor KW, Bramson HN, Stuart JD, et al. Frye SV, et al. Among authors: batchelor kw. J Med Chem. 1995 Jul 7;38(14):2621-7. doi: 10.1021/jm00014a015. J Med Chem. 1995. PMID: 7629802
Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat.
Stuart JD, Lee FW, Simpson Noel D, Kadwell SH, Overton LK, Hoffman CR, Kost TA, Tippin TK, Yeager RL, Batchelor KW, Bramson HN. Stuart JD, et al. Among authors: batchelor kw. Biochem Pharmacol. 2001 Oct 1;62(7):933-42. doi: 10.1016/s0006-2952(01)00728-6. Biochem Pharmacol. 2001. PMID: 11543729
NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo.
Zhang L, Han J, Jackson AL, Clark LN, Kilgore J, Guo H, Livingston N, Batchelor K, Yin Y, Gilliam TP, Gehrig PA, Sheng X, Zhou C, Bae-Jump VL. Zhang L, et al. J Hematol Oncol. 2016 Sep 21;9(1):91. doi: 10.1186/s13045-016-0325-7. J Hematol Oncol. 2016. PMID: 27655410 Free PMC article.
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