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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: bastian a. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.
Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Gangjee A, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA. Gangjee A, et al. Among authors: bastian a. Bioorg Med Chem. 2013 Apr 1;21(7):1857-64. doi: 10.1016/j.bmc.2013.01.040. Epub 2013 Jan 31. Bioorg Med Chem. 2013. PMID: 23434139 Free PMC article.
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: bastian a. Bioorg Med Chem. 2015 May 15;23(10):2408-23. doi: 10.1016/j.bmc.2015.03.061. Epub 2015 Mar 30. Bioorg Med Chem. 2015. PMID: 25882519 Free PMC article.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Pavana RK, Choudhary S, Bastian A, Ihnat MA, Bai R, Hamel E, Gangjee A. Pavana RK, et al. Among authors: bastian a. Bioorg Med Chem. 2017 Jan 15;25(2):545-556. doi: 10.1016/j.bmc.2016.11.026. Epub 2016 Nov 15. Bioorg Med Chem. 2017. PMID: 27894589 Free PMC article.
Identification of novel drugs to target dormant micrometastases.
Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Hurst RE, et al. Among authors: bastian a. BMC Cancer. 2015 May 14;15:404. doi: 10.1186/s12885-015-1409-4. BMC Cancer. 2015. PMID: 25971923 Free PMC article.
378 results