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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Basile G, et al. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. Cell Metab. 2023. PMID: 37339634 Free PMC article.
Human duct cells contribute to β cell compensation in insulin resistance.
Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Dirice E, et al. Among authors: basile g. JCI Insight. 2019 Apr 18;4(8):e99576. doi: 10.1172/jci.insight.99576. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996131 Free PMC article.
How, When, and Where Do Human β-Cells Regenerate?
Basile G, Kulkarni RN, Morgan NG. Basile G, et al. Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8. Curr Diab Rep. 2019. PMID: 31250214 Free PMC article. Review.
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Dirice E, et al. Among authors: basile g. Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6. Nat Metab. 2019. PMID: 31423480 Free PMC article.
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Shirakawa J, et al. Among authors: basile g. Diabetologia. 2020 Mar;63(3):577-587. doi: 10.1007/s00125-019-05071-w. Epub 2020 Jan 3. Diabetologia. 2020. PMID: 31897526 Free PMC article.
Emerging diabetes therapies: Bringing back the β-cells.
Basile G, Qadir MMF, Mauvais-Jarvis F, Vetere A, Shoba V, Modell AE, Pastori RL, Russ HA, Wagner BK, Dominguez-Bendala J. Basile G, et al. Mol Metab. 2022 Jun;60:101477. doi: 10.1016/j.molmet.2022.101477. Epub 2022 Mar 21. Mol Metab. 2022. PMID: 35331962 Free PMC article. Review.
573 results