Barreca ML - Search Results

1

Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.

Bartolini D, Bührmann M, Barreca ML, Manfroni G, Cecchetti V, Rauh D, Galli F. Bartolini D, et al. Among authors: barreca ml. Biochem Biophys Res Commun. 2019 Apr 9;511(3):579-586. doi: 10.1016/j.bbrc.2019.02.063. Epub 2019 Feb 27. Biochem Biophys Res Commun. 2019. PMID: 30824186

2

A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.

Massari S, Daelemans D, Barreca ML, Knezevich A, Sabatini S, Cecchetti V, Marcello A, Pannecouque C, Tabarrini O. Massari S, et al. Among authors: barreca ml. J Med Chem. 2010 Jan 28;53(2):641-8. doi: 10.1021/jm901211d. J Med Chem. 2010. PMID: 19958026

3

Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.

Barreca ML, Iraci N, Manfroni G, Cecchetti V. Barreca ML, et al. Future Med Chem. 2011 Jun;3(8):1027-55. doi: 10.4155/fmc.11.53. Future Med Chem. 2011. PMID: 21707403 Review.

4

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

Manfroni G, Meschini F, Barreca ML, Leyssen P, Samuele A, Iraci N, Sabatini S, Massari S, Maga G, Neyts J, Cecchetti V. Manfroni G, et al. Among authors: barreca ml. Bioorg Med Chem. 2012 Jan 15;20(2):866-76. doi: 10.1016/j.bmc.2011.11.061. Epub 2011 Dec 3. Bioorg Med Chem. 2012. PMID: 22197397

5

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.

Barreca ML, Manfroni G, Leyssen P, Winquist J, Kaushik-Basu N, Paeshuyse J, Krishnan R, Iraci N, Sabatini S, Tabarrini O, Basu A, Danielson UH, Neyts J, Cecchetti V. Barreca ML, et al. J Med Chem. 2013 Mar 28;56(6):2270-82. doi: 10.1021/jm301643a. Epub 2013 Mar 7. J Med Chem. 2013. PMID: 23409936 Free PMC article.

6

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.

Martelli A, Manfroni G, Sabbatini P, Barreca ML, Testai L, Novelli M, Sabatini S, Massari S, Tabarrini O, Masiello P, Calderone V, Cecchetti V. Martelli A, et al. Among authors: barreca ml. J Med Chem. 2013 Jun 13;56(11):4718-28. doi: 10.1021/jm400435a. Epub 2013 May 28. J Med Chem. 2013. PMID: 23662847

7

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

Sabatini S, Gosetto F, Iraci N, Barreca ML, Massari S, Sancineto L, Manfroni G, Tabarrini O, Dimovska M, Kaatz GW, Cecchetti V. Sabatini S, et al. Among authors: barreca ml. J Med Chem. 2013 Jun 27;56(12):4975-89. doi: 10.1021/jm400262a. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23710549

8

Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.

Barreca ML, Iraci N, Manfroni G, Gaetani R, Guercini C, Sabatini S, Tabarrini O, Cecchetti V. Barreca ML, et al. J Chem Inf Model. 2014 Feb 24;54(2):481-97. doi: 10.1021/ci400367m. Epub 2013 Sep 5. J Chem Inf Model. 2014. PMID: 23952658

9

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Manfroni G, Cannalire R, Barreca ML, Kaushik-Basu N, Leyssen P, Winquist J, Iraci N, Manvar D, Paeshuyse J, Guhamazumder R, Basu A, Sabatini S, Tabarrini O, Danielson UH, Neyts J, Cecchetti V. Manfroni G, et al. Among authors: barreca ml. J Med Chem. 2014 Mar 13;57(5):1952-63. doi: 10.1021/jm401362f. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24131104 Free PMC article.

10

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity.

Sancineto L, Iraci N, Massari S, Attanasio V, Corazza G, Barreca ML, Sabatini S, Manfroni G, Avanzi NR, Cecchetti V, Pannecouque C, Marcello A, Tabarrini O. Sancineto L, et al. Among authors: barreca ml. ChemMedChem. 2013 Dec;8(12):1941-53. doi: 10.1002/cmdc.201300287. Epub 2013 Oct 21. ChemMedChem. 2013. PMID: 24150998

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