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AQP5 enriches for stem cells and cancer origins in the distal stomach.
Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, Wong E, Fatehullah A, Sheng T, Ho SWT, Grabsch HI, Srivastava S, Teh M, Denil SLIJ, Mustafah S, Tan P, Shabbir A, So J, Yeoh KG, Barker N. Tan SH, et al. Among authors: barker n. Nature. 2020 Feb;578(7795):437-443. doi: 10.1038/s41586-020-1973-x. Epub 2020 Feb 5. Nature. 2020. PMID: 32025032 Free article.
Crypt stem cells as the cells-of-origin of intestinal cancer.
Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Barker N, et al. Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17. Nature. 2009. PMID: 19092804
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Sato T, et al. Among authors: barker n. Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28. Nature. 2011. PMID: 21113151 Free PMC article.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. de Lau W, et al. Among authors: barker n. Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337. Nature. 2011. PMID: 21727895
450 results