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A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Kaptein SJF, Goethals O, Kiemel D, Marchand A, Kesteleyn B, Bonfanti JF, Bardiot D, Stoops B, Jonckers THM, Dallmeier K, Geluykens P, Thys K, Crabbe M, Chatel-Chaix L, Münster M, Querat G, Touret F, de Lamballerie X, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Van Loock M, Neyts J. Kaptein SJF, et al. Among authors: bardiot d. Nature. 2021 Oct;598(7881):504-509. doi: 10.1038/s41586-021-03990-6. Epub 2021 Oct 6. Nature. 2021. PMID: 34616043
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Vandyck K, Abdelnabi R, Gupta K, Jochmans D, Jekle A, Deval J, Misner D, Bardiot D, Foo CS, Liu C, Ren S, Beigelman L, Blatt LM, Boland S, Vangeel L, Dejonghe S, Chaltin P, Marchand A, Serebryany V, Stoycheva A, Chanda S, Symons JA, Raboisson P, Neyts J. Vandyck K, et al. Among authors: bardiot d. Biochem Biophys Res Commun. 2021 May 28;555:134-139. doi: 10.1016/j.bbrc.2021.03.096. Epub 2021 Mar 26. Biochem Biophys Res Commun. 2021. PMID: 33813272 Free PMC article.
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Kaptein SJF, Goethals O, Kiemel D, Marchand A, Kesteleyn B, Bonfanti JF, Bardiot D, Stoops B, Jonckers THM, Dallmeier K, Geluykens P, Thys K, Crabbe M, Chatel-Chaix L, Münster M, Querat G, Touret F, de Lamballerie X, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Van Loock M, Neyts J. Kaptein SJF, et al. Among authors: bardiot d. Nature. 2021 Nov;599(7883):E2. doi: 10.1038/s41586-021-04123-9. Nature. 2021. PMID: 34671169 No abstract available.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Bardiot D, Vangeel L, Koukni M, Arzel P, Zwaagstra M, Lyoo H, Wanningen P, Ahmad S, Zhang L, Sun X, Delpal A, Eydoux C, Guillemot JC, Lescrinier E, Klaassen H, Leyssen P, Jochmans D, Castermans K, Hilgenfeld R, Robinson C, Decroly E, Canard B, Snijder EJ, van Hemert MJ, van Kuppeveld F, Chaltin P, Neyts J, De Jonghe S, Marchand A. Bardiot D, et al. Molecules. 2022 Feb 4;27(3):1052. doi: 10.3390/molecules27031052. Molecules. 2022. PMID: 35164317 Free PMC article.
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