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Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM. Perni M, et al. Among authors: barbut d. ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28. ACS Chem Biol. 2018. PMID: 29953201
Gastrointestinal Immunity and Alpha-Synuclein.
Barbut D, Stolzenberg E, Zasloff M. Barbut D, et al. J Parkinsons Dis. 2019;9(s2):S313-S322. doi: 10.3233/JPD-191702. J Parkinsons Dis. 2019. PMID: 31594249 Free PMC article. Review.
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine.
Errico S , Lucchesi G , Odino D , Muscat S , Capitini C , Bugelli C , Canale C , Ferrando R , Grasso G , Barbut D , Calamai M , Danani A , Zasloff M , Relini A , Caminati G , Vendruscolo M , Chiti F . Errico S , et al. Among authors: barbut d. Nanoscale. 2020 Nov 19;12(44):22596-22614. doi: 10.1039/d0nr05285j. Nanoscale. 2020. PMID: 33150350
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Perni M, van der Goot A, Limbocker R, van Ham TJ, Aprile FA, Xu CK, Flagmeier P, Thijssen K, Sormanni P, Fusco G, Chen SW, Challa PK, Kirkegaard JB, Laine RF, Ma KY, Müller MBD, Sinnige T, Kumita JR, Cohen SIA, Seinstra R, Kaminski Schierle GS, Kaminski CF, Barbut D, De Simone A, Knowles TPJ, Zasloff M, Nollen EAA, Vendruscolo M, Dobson CM. Perni M, et al. Among authors: barbut d. Front Cell Dev Biol. 2021 Mar 22;9:552549. doi: 10.3389/fcell.2021.552549. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33829010 Free PMC article.
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
Limbocker R, Staats R, Chia S, Ruggeri FS, Mannini B, Xu CK, Perni M, Cascella R, Bigi A, Sasser LR, Block NR, Wright AK, Kreiser RP, Custy ET, Meisl G, Errico S, Habchi J, Flagmeier P, Kartanas T, Hollows JE, Nguyen LT, LeForte K, Barbut D, Kumita JR, Cecchi C, Zasloff M, Knowles TPJ, Dobson CM, Chiti F, Vendruscolo M. Limbocker R, et al. Among authors: barbut d. Front Neurosci. 2021 Jun 18;15:680026. doi: 10.3389/fnins.2021.680026. eCollection 2021. Front Neurosci. 2021. PMID: 34220435 Free PMC article.
Targeting neurons in the gastrointestinal tract to treat Parkinson's disease.
Hauser RA, Sutherland D, Madrid JA, Rol MA, Frucht S, Isaacson S, Pagan F, Maddux BN, Li G, Tse W, Walter BL, Kumar R, Kremens D, Lew MF, Ellenbogen A, Oguh O, Vasquez A, Kinney W, Lowery M, Resnick M, Huff N, Posner J, Ballman KV, Harvey BE, Camilleri M, Zasloff M, Barbut D. Hauser RA, et al. Among authors: barbut d. Clin Park Relat Disord. 2019 Jul 2;1:2-7. doi: 10.1016/j.prdoa.2019.06.001. eCollection 2019. Clin Park Relat Disord. 2019. PMID: 34316590 Free PMC article.
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine.
Errico S, Ramshini H, Capitini C, Canale C, Spaziano M, Barbut D, Calamai M, Zasloff M, Oropesa-Nuñez R, Vendruscolo M, Chiti F. Errico S, et al. Among authors: barbut d. ACS Chem Neurosci. 2021 Sep 1;12(17):3189-3202. doi: 10.1021/acschemneuro.1c00327. Epub 2021 Aug 12. ACS Chem Neurosci. 2021. PMID: 34382791 Free PMC article.
57 results