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Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
J Med Chem. 2018 Apr 12;61(7):2823-2836. doi: 10.1021/acs.jmedchem.7b01625. Epub 2018 Mar 15.
J Med Chem. 2018.
PMID: 29517911
The potent small molecule integrin antagonist THR-687 is a promising next-generation therapy for retinal vascular disorders.
Hu TT, Vanhove M, Porcu M, Van Hove I, Van Bergen T, Jonckx B, Barbeaux P, Vermassen E, Feyen JHM.
Hu TT, et al. Among authors: barbeaux p.
Exp Eye Res. 2019 Mar;180:43-52. doi: 10.1016/j.exer.2018.11.022. Epub 2018 Nov 22.
Exp Eye Res. 2019.
PMID: 30472075
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Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 1. THR-149.
Vanhove M, Noppen B, Wagner JM, Van Bergen T, Barbeaux P, Stitt AW.
Vanhove M, et al. Among authors: barbeaux p.
J Pharmacokinet Pharmacodyn. 2021 Dec;48(6):825-836. doi: 10.1007/s10928-021-09773-w. Epub 2021 Jul 23.
J Pharmacokinet Pharmacodyn. 2021.
PMID: 34302260
Free PMC article.
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Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems.
Jonckx B, Porcu M, Candi A, Etienne I, Barbeaux P, Feyen JHM.
Jonckx B, et al. Among authors: barbeaux p.
J Ophthalmol. 2017;2017:2060765. doi: 10.1155/2017/2060765. Epub 2017 Oct 29.
J Ophthalmol. 2017.
PMID: 29214073
Free PMC article.
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Autolytic degradation of ocriplasmin: a complex mechanism unraveled by mutational analysis.
Noppen B, Fonteyn L, Aerts F, De Vriese A, De Maeyer M, Le Floch F, Barbeaux P, Zwaal R, Vanhove M.
Noppen B, et al. Among authors: barbeaux p.
Protein Eng Des Sel. 2014 Jul;27(7):215-23. doi: 10.1093/protein/gzu015. Epub 2014 May 1.
Protein Eng Des Sel. 2014.
PMID: 24795342
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Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains.
Staelens S, Desmet J, Ngo TH, Vauterin S, Pareyn I, Barbeaux P, Van Rompaey I, Stassen JM, Deckmyn H, Vanhoorelbeke K.
Staelens S, et al. Among authors: barbeaux p.
Mol Immunol. 2006 Mar;43(8):1243-57. doi: 10.1016/j.molimm.2005.07.018. Epub 2005 Aug 22.
Mol Immunol. 2006.
PMID: 16118019
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The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons.
Fontayne A, Meiring M, Lamprecht S, Roodt J, Demarsin E, Barbeaux P, Deckmyn H.
Fontayne A, et al. Among authors: barbeaux p.
Thromb Haemost. 2008 Oct;100(4):670-7.
Thromb Haemost. 2008.
PMID: 18841291
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