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Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains.
Staelens S, Desmet J, Ngo TH, Vauterin S, Pareyn I, Barbeaux P, Van Rompaey I, Stassen JM, Deckmyn H, Vanhoorelbeke K. Staelens S, et al. Among authors: barbeaux p. Mol Immunol. 2006 Mar;43(8):1243-57. doi: 10.1016/j.molimm.2005.07.018. Epub 2005 Aug 22. Mol Immunol. 2006. PMID: 16118019