Bar-Peled L - Search Results

1

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. Bar-Peled L, et al. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. Science. 2013. PMID: 23723238 Free PMC article.

2

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.

3

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Sancak Y, et al. Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8. Cell. 2010. PMID: 20381137 Free PMC article.

4

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. Zoncu R, et al. Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056. Science. 2011. PMID: 22053050 Free PMC article.

5

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Bar-Peled L, et al. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. Cell. 2012. PMID: 22980980 Free PMC article.

6

SnapShot: mTORC1 signaling at the lysosomal surface.

Bar-Peled L, Sabatini DM. Bar-Peled L, et al. Cell. 2012 Dec 7;151(6):1390-1390.e1. doi: 10.1016/j.cell.2012.11.038. Cell. 2012. PMID: 23217718 Free article. No abstract available.

7

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. Tsun ZY, et al. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. Mol Cell. 2013. PMID: 24095279 Free PMC article.

8

Regulation of mTORC1 by amino acids.

Bar-Peled L, Sabatini DM. Bar-Peled L, et al. Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31. Trends Cell Biol. 2014. PMID: 24698685 Free PMC article. Review.

9

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM. Chantranupong L, et al. Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25. Cell Rep. 2014. PMID: 25263562 Free PMC article.

10

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Wang S, et al. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. Science. 2015. PMID: 25567906 Free PMC article.

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