Bamford M - Search Results

1

Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.

Richards D, Bamford M, Liefaard L, Haque N, Lewis G, Storey J, Fernando D, Kumar S, Thompson D, Holmes DS. Richards D, et al. Among authors: bamford m. Br J Pharmacol. 2020 Apr;177(8):1853-1864. doi: 10.1111/bph.14956. Epub 2020 Feb 11. Br J Pharmacol. 2020. PMID: 31877231 Free PMC article.

2

4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists.

Procopiou PA, Ancliff RA, Bamford MJ, Browning C, Connor H, Davies S, Fogden YC, Hodgson ST, Holmes DS, Looker BE, Morriss KM, Parr CA, Pickup EA, Sehmi SS, White GV, Watts CJ, Wilson DM, Woodrow MD. Procopiou PA, et al. Among authors: bamford mj. J Med Chem. 2007 Dec 27;50(26):6706-17. doi: 10.1021/jm0708228. Epub 2007 Dec 6. J Med Chem. 2007. PMID: 18052318

3

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis.

McBride A, Hoy AM, Bamford MJ, Mossakowska DE, Ruediger MP, Griggs J, Desai S, Simpson K, Caballero-Hernandez I, Iredale JP, Pell T, Aucott RL, Holmes DS, Webster SP, Fallowfield JA. McBride A, et al. Among authors: bamford mj. Sci Rep. 2017 Sep 7;7(1):10806. doi: 10.1038/s41598-017-10521-9. Sci Rep. 2017. PMID: 28883402 Free PMC article.

4

Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-acetylglucosamine sugar with simple C2-symmetric 1,2-diols.

Prodger JC, Bamford MJ, Bird MI, Gore PM, Holmes DS, Priest R, Saez V. Prodger JC, et al. Among authors: bamford mj. Bioorg Med Chem. 1996 Jun;4(6):793-801. doi: 10.1016/0968-0896(96)00055-7. Bioorg Med Chem. 1996. PMID: 8818228

5

GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.

Pearce AC, Bamford MJ, Barber R, Bridges A, Convery MA, Demetriou C, Evans S, Gobbetti T, Hirst DJ, Holmes DS, Hutchinson JP, Jayne S, Lezina L, McCabe MT, Messenger C, Morley J, Musso MC, Scott-Stevens P, Manso AS, Schofield J, Slocombe T, Somers D, Walker AL, Wyce A, Zhang XP, Wagner SD. Pearce AC, et al. J Biol Chem. 2021 Aug;297(2):100928. doi: 10.1016/j.jbc.2021.100928. Epub 2021 Jul 15. J Biol Chem. 2021. PMID: 34274316 Free PMC article.

6

The discovery of the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Briggs MA, Calver AR, Crook B, Davis RP, Davis S, Dean DK, Harris L, Heightman TD, Panchal T, Parr CA, Quashie N, Steadman JG, Schogger J, Sehmi SS, Stean TO, Takle AK, Trail BK, White T, Witherington J, Worby A, Medhurst AD. Wilson DM, et al. Among authors: bamford mj. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6897-901. doi: 10.1016/j.bmcl.2013.09.089. Epub 2013 Oct 5. Bioorg Med Chem Lett. 2013. PMID: 24161834

7

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Brackenborough K, Briggs MA, Brough S, Calver AR, Crook B, Davis RK, Davis RP, Davis S, Dean DK, Harris L, Heslop T, Holland V, Jeffrey P, Panchal TA, Parr CA, Quashie N, Schogger J, Sehmi SS, Stean TO, Steadman JG, Trail B, Wald J, Worby A, Takle AK, Witherington J, Medhurst AD. Wilson DM, et al. Among authors: bamford mj. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6890-6. doi: 10.1016/j.bmcl.2013.09.090. Epub 2013 Oct 5. Bioorg Med Chem Lett. 2013. PMID: 24269482

8

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.

Bamford MJ, Alberti MJ, Bailey N, Davies S, Dean DK, Gaiba A, Garland S, Harling JD, Jung DK, Panchal TA, Parr CA, Steadman JG, Takle AK, Townsend JT, Wilson DM, Witherington J. Bamford MJ, et al. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6. doi: 10.1016/j.bmcl.2005.05.021. Bioorg Med Chem Lett. 2005. PMID: 15950465

9

Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

Panchal T, Bailey N, Bamford M, Demont E, Elliott R, Farre-Gutierrez I, Garton N, Hayhow T, Hutley G, Naylor A. Panchal T, et al. Among authors: bamford m. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6813-7. doi: 10.1016/j.bmcl.2009.07.002. Epub 2009 Jul 4. Bioorg Med Chem Lett. 2009. PMID: 19846298

10

A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships.

Humber DC, Bamford MJ, Bethell RC, Cammack N, Cobley K, Evans DN, Gray NM, Hann MM, Orr DC, Saunders J, et al. Humber DC, et al. Among authors: bamford mj. J Med Chem. 1993 Oct 15;36(21):3120-8. doi: 10.1021/jm00073a011. J Med Chem. 1993. PMID: 8230098

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