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Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Ballet S, et al. J Med Chem. 2011 Apr 14;54(7):2467-76. doi: 10.1021/jm1016285. Epub 2011 Mar 17. J Med Chem. 2011. PMID: 21413804 Free PMC article.
In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera.
Guillemyn K, Kleczkowska P, Novoa A, Vandormael B, Van den Eynde I, Kosson P, Asim MF, Schiller PW, Spetea M, Lipkowski AW, Tourwé D, Ballet S. Guillemyn K, et al. Among authors: ballet s. Mol Brain. 2012 Jan 30;5:4. doi: 10.1186/1756-6606-5-4. Mol Brain. 2012. PMID: 22289619 Free PMC article.
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
Novoa A, Van Dorpe S, Wynendaele E, Spetea M, Bracke N, Stalmans S, Betti C, Chung NN, Lemieux C, Zuegg J, Cooper MA, Tourwé D, De Spiegeleer B, Schiller PW, Ballet S. Novoa A, et al. Among authors: ballet s. J Med Chem. 2012 Nov 26;55(22):9549-61. doi: 10.1021/jm3008079. Epub 2012 Nov 12. J Med Chem. 2012. PMID: 23102273 Free PMC article.
Hybrid opioid/non-opioid ligands in pain research.
Kleczkowska P, Lipkowski AW, Tourwé D, Ballet S. Kleczkowska P, et al. Among authors: ballet s. Curr Pharm Des. 2013;19(42):7435-50. doi: 10.2174/138161281942140105165646. Curr Pharm Des. 2013. PMID: 23448481 Review.
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, Van Duppen J, Przewlocka B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S. Guillemyn K, et al. Among authors: ballet s. Eur J Med Chem. 2015 Mar 6;92:64-77. doi: 10.1016/j.ejmech.2014.12.033. Epub 2014 Dec 19. Eur J Med Chem. 2015. PMID: 25544687 Free PMC article.
Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.
Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S. Guillemyn K, et al. Among authors: ballet s. J Med Chem. 2016 Apr 28;59(8):3777-92. doi: 10.1021/acs.jmedchem.5b01976. Epub 2016 Apr 14. J Med Chem. 2016. PMID: 27035422 Free PMC article.
176 results